MP59-19 PERIOPERATIVE SERUM CYTOKINE LEVELS IN PATIENTS TREATED WITH ROBOT-ASSISTED LAPAROSCOPIC PARTIAL NEPHRECTOMY

Abstract

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy V (MP59)1 Sep 2021MP59-19 PERIOPERATIVE SERUM CYTOKINE LEVELS IN PATIENTS TREATED WITH ROBOT-ASSISTED LAPAROSCOPIC PARTIAL NEPHRECTOMY Atsushi Koizumi, Shintaro Narita, Soki Kashima, Ryohei Yamamoto, Taketoshi Nara, Mingguo Huang, Kazuyuki Numakura, Mitsuru Saito, Shigeru Satoh, and Tomonori Habuchi Atsushi KoizumiAtsushi Koizumi More articles by this author , Shintaro NaritaShintaro Narita More articles by this author , Soki KashimaSoki Kashima More articles by this author , Ryohei YamamotoRyohei Yamamoto More articles by this author , Taketoshi NaraTaketoshi Nara More articles by this author , Mingguo HuangMingguo Huang More articles by this author , Kazuyuki NumakuraKazuyuki Numakura More articles by this author , Mitsuru SaitoMitsuru Saito More articles by this author , Shigeru SatohShigeru Satoh More articles by this author , and Tomonori HabuchiTomonori Habuchi More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002094.19AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: We assessed the impact of the perioperative serum levels of six inflammatory cytokines on clinical outcomes in patients with renal cell carcinoma (RCC) treated with robot-assisted laparoscopic partial nephrectomy (RAPN). METHODS: We included 138 patients who underwent RAPN for localized RCC between 2013 and 2020. We measured six inflammatory cytokines (interleukin [IL]-10, IL-6, IL-8, IL-1b, IL-12p70, and tumor necrosis factor [TNF]-a) using the BD Cytometric Bead Array (BD, Tokyo, Japan), along with white blood cell count (WBC) and C-reactive protein (CRP) level. Measurements were performed before the operation (pre-OP), immediately after the operation (post-OP), and at postoperative Day 1 (POD1). We statistically investigated the relationship between clinical outcomes and the levels of inflammatory mediators. RESULTS: The median tumor diameter was 30 mm; 116 (84.1%) and 22 (15.9%) patients had cT1a and cT1b disease, respectively. The median R.E.N.A.L nephrometry score was 7. The levels of WBC, CRP, and IL-10 at post-OP and POD1 were significantly higher than those measured at pre-OP (each, p<0.05). The levels of IL-6 and IL-8 at post-OP were significantly higher than those detected at pre-OP (each, p<0.05). The univariate analysis showed that the surgical approach, operative time, R.E.N.A.L nephrometry score, and clinical stage were significantly associated with higher levels of IL-6 and IL-10 at POD1. The multivariate analysis showed that the retroperitoneal approach was an independent risk factor for a high IL-10 level at POD1 (p=0.031). Regarding the impact of cytokine levels on postoperative renal function, the patients with worse renal function had a significantly higher IL-6 level at POD1 than those with better renal function (53. 3 pg/mL vs. 40. 4 pg/mL, respectively; p=0.038). The multivariate analysis showed that a high IL-6 level at POD1 was an independent risk factor for deterioration of renal function at 1 month (p=0.039). There were no relationships between serum cytokine levels and oncological outcomes. CONCLUSIONS: In RAPN, the retroperitoneal approach was linked to a risk for increased postoperative serum levels of inflammatory cytokines. The serum level of IL-6 at POD1 was associated with postoperative renal deterioration in patients with RCC treated with RAPN. Source of Funding: None. © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e1038-e1038 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Atsushi Koizumi More articles by this author Shintaro Narita More articles by this author Soki Kashima More articles by this author Ryohei Yamamoto More articles by this author Taketoshi Nara More articles by this author Mingguo Huang More articles by this author Kazuyuki Numakura More articles by this author Mitsuru Saito More articles by this author Shigeru Satoh More articles by this author Tomonori Habuchi More articles by this author Expand All Advertisement Loading ...