MP59-14 LONG TERM ONCOLOGIC OUTCOMES OF PARTIAL NEPHRECTOMY FOR CYSTIC RENAL TUMORS: A PROPENSITY SCORE MATCHED-PAIR COMPARISON OF CYSTIC VERSUS CLEAR CELL CARCINOMA FROM A SINGLE CENTER EXPERIENCE

Abstract

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy V (MP59)1 Sep 2021MP59-14 LONG TERM ONCOLOGIC OUTCOMES OF PARTIAL NEPHRECTOMY FOR CYSTIC RENAL TUMORS: A PROPENSITY SCORE MATCHED-PAIR COMPARISON OF CYSTIC VERSUS CLEAR CELL CARCINOMA FROM A SINGLE CENTER EXPERIENCE Mariaconsiglia Ferriero, Riccardo Mastroianni, Gabriele Tuderti, Manuela Costantini, Umberto Anceschi, Leonardo Misuraca, Aldo Brassetti, Salvatore Guaglianone, Alfredo Maria Bove, Michele Gallucci, and Giuseppe Simone Mariaconsiglia FerrieroMariaconsiglia Ferriero More articles by this author , Riccardo MastroianniRiccardo Mastroianni More articles by this author , Gabriele TudertiGabriele Tuderti More articles by this author , Manuela CostantiniManuela Costantini More articles by this author , Umberto AnceschiUmberto Anceschi More articles by this author , Leonardo MisuracaLeonardo Misuraca More articles by this author , Aldo BrassettiAldo Brassetti More articles by this author , Salvatore GuaglianoneSalvatore Guaglianone More articles by this author , Alfredo Maria BoveAlfredo Maria Bove More articles by this author , Michele GallucciMichele Gallucci More articles by this author , and Giuseppe SimoneGiuseppe Simone More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002094.14AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Few data are available on survival outcomes of partial nephrectomy performed for cystic renal tumors. We present long term oncological outcomes of cystic (cystRCC) versus clear cell cell carcinoma (ccRCC) in a propensity score matched (PSM) analysis. METHODS: Our prospectively maintained “renal cancer “database was queried for off-clamp partial nephrectomy and cystic or clear cell variant histology at pathologic examination. The two groups were compared for the main clinical features. A 1:3 PSM analysis was employed to reduce covariate imbalance to <10% and generated two population homogeneous for age, gender, tumour size, pT stage and Fuhrman Grade. Student-t and Chi-Square test were used for continuous and categorical variables, respectively. Five-yr disease free survival (DFS) and cancer specific survival (CSS) were compared between the two study cohorts using log rank test. Age, gender, grade, pT stage, tumor size, necrosis and variant histology were included in a univariable Cox regression analysis to identify predictors of disease progression after partial nephrectomy. RESULTS: Clinical and pathological features of the study cohorts were reported in Table 1. Overall, 85 cases were cystRCC and 774 were ccRCC at pathologic examination. After applying the PSM analysis, two cohorts were selected, including 64 cystRCC and 170 ccRCC. (Table 1) Five-yr DFS and CSS were 84.1%, 97.2% versus 90.1% and 100 % for ccRCC and cystRCC, respectively. (log rank p=0.035 and p=0.146, respectively. (Fig. 1) At univariable regression analysis ccRCC histology was the only independent predictor of DFS (HR 2.96 95%CI 21.031-8.478, p=0.044). CONCLUSIONS: At 5-yr evaluation cystRCC showed favorable oncological outcomes after partial nephrectomy. Clear cell variant histology predicts less favorable progression probability than cystic tumors. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e1035-e1036 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mariaconsiglia Ferriero More articles by this author Riccardo Mastroianni More articles by this author Gabriele Tuderti More articles by this author Manuela Costantini More articles by this author Umberto Anceschi More articles by this author Leonardo Misuraca More articles by this author Aldo Brassetti More articles by this author Salvatore Guaglianone More articles by this author Alfredo Maria Bove More articles by this author Michele Gallucci More articles by this author Giuseppe Simone More articles by this author Expand All Advertisement Loading ...