MP58-19 INVESTIGATIONS OF THE MICRO-ELEMENTAL COMPOSITION OF THE URINARY STONES IN ADULTS AND CHILDREN: A COMPARATIVE PROSPECTIVE STUDY

Abstract

You have accessJournal of UrologyStone Disease: Basic Research & Pathophysiology I1 Apr 2016MP58-19 INVESTIGATIONS OF THE MICRO-ELEMENTAL COMPOSITION OF THE URINARY STONES IN ADULTS AND CHILDREN: A COMPARATIVE PROSPECTIVE STUDY Mahmoud El-Naggar, Emad Elsobky, and Bedeir Ali-El-Dein Mahmoud El-NaggarMahmoud El-Naggar More articles by this author , Emad ElsobkyEmad Elsobky More articles by this author , and Bedeir Ali-El-DeinBedeir Ali-El-Dein More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.817AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The routine analysis of urinary stones by Fourier-Transform Infrared Spectroscopy (FT-IR) is limited only to the identification of the stone biochemical structure. The exact micro-elemental components of the urinary stones have not yet been defined and could not be detected by ordinary stone analysis techniques. The objective of this study is to compare and quantitate the micro-elemental components of the urinary stones in both adults and children in association with the biochemical structure. METHODS This prospective study included 250 urinary stones (125 from adults and 125 from children) that were collected after either open or endoscopic procedures. All the stones were cleaned, dried and weighed. The stones were subjected to biochemical analysis by using Fourier-Transform Infrared Spectroscopy (FT-IR) and microanalysis of major and minor elements (22 elements in each stone) by using inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES). Student T and ANOVA tests were used for comparative statistical analyses. RESULTS The microanalysis of the stones by ICP-OES showed that both groups of urinary stones (adults and children) had variable high concentrations of heavy metals and trace elements (HMTE). 11 elements (Al, B, Ba, Cd, Cr, Fe, K, Na, Ni, Pb and Sr) were significantly higher in pediatric than adult urinary stones (p <0.05). Ca, Mn and Se contents were significantly higher in adult stones than pediatric stones. Ca oxalate monohydrate (COM) component was common in both adult (82%) and pediatric stones (78%). Ca oxalate dihydrate (COD) component was significantly higher in adults than pediatric stones. Ammonium urate component of stones was detected in 28% of pediatric stones and was absent in adult stones. There was no statistical significant difference between adult and children regarding stone biochemical types (P>0.05). CONCLUSIONS Pediatric urinary stones contained many heavy metals and trace elements in variable but significant concentrations. The biochemical types of urinary stones are not affected neither by age nor gender. The current results indicate a possible role of heavy metals and trace elements in stone formation. The source of HMTE may be environmental, water and food pollution. Further studies are needed to the inter-relationship between the crystalline components and the micro-structure elements. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e783 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Mahmoud El-Naggar More articles by this author Emad Elsobky More articles by this author Bedeir Ali-El-Dein More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...