MP56-10 COMPARATIVE ANALYSIS OF THE RESULTS OF TREATMENT OF PATIENTS WITH RECURRENT URETHRAL STRICTURE USING PLATELET-RICH PLASMA

Abstract

You have accessJournal of UrologyTrauma/Reconstruction/Diversion: Urethral Reconstruction (including Stricture, Diverticulum) III (MP56)1 Sep 2021MP56-10 COMPARATIVE ANALYSIS OF THE RESULTS OF TREATMENT OF PATIENTS WITH RECURRENT URETHRAL STRICTURE USING PLATELET-RICH PLASMA Sergey Kotov, and Mikhail Iritsyan Sergey KotovSergey Kotov More articles by this author , and Mikhail IritsyanMikhail Iritsyan More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002086.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Treatment of patients with recurrent urethral stricture requires not only the improvement of surgical techniques, but also the influence on the pathogenetic mechanisms of the formation of urethral stricture. We have previously demonstrated that platelet-rich plasma (PRP) leads to stimulation of regeneration and organization of the intercellular matrix in an experimental model of urethroplasty. To evaluate the clinical effectiveness of reconstructive plastic surgery using platelet-rich plasma in patients with recurrent urethral stricture. METHODS: A comparative analysis of the results of surgical treatment of patients with recurrent urethral stricture with and without the use of platelet-rich plasma was carried out at the University Clinic of Urology of the Pirogov Russian National Research Medical University. A total of 60 patients were included in the study. The main group consisted of 30 patients who were injected with PRP into the spongy body in the operation area. In the control group (30 patients), phys. solution was entered in the same volumes. According to the medians of length and age, localization and etiology, urethral strictures were comparable in the groups. The median maximum urination rate before surgery was 4.7 ml /s (1,7 - 11). According to etiological factors there were iatrogenic strictures in 45 (75%) cases, traumatic – 7 (11.7%), infectious – 2 (3.3%), posthypospadial - 6 (10%). The urethral catheter was removed after surgery in the absence of a contrast agent leak during urethrography. RESULTS: In the main group: anastomotic urethroplasty – 17 patients, augmentation urethroplasty - 9, multi - stage urethroplasty/perineostomy-4. The following operations were performed in the control group: anastomotic urethroplasty in 24 cases, augmentation urethroplasty-in 4 cases, с in 2 cases. The median (min-max) follow – up after surgery was 12 years (6-22 months). The effectiveness in the main group was 93.3%. In 2 cases, a relapse was noted. In the control group, the efficiency was 76.7%. Relapse occurred in 7 cases. The median period of bladder drainage with a urethral catheter after surgery was 14 and 7 days in the control and main groups, respectively (p< 0, 05). The frequency of infectious complications (urethritis, orchepididymitis, p/o wound suppuration) was significantly lower in the main group (p<0.05). The median postoperative Qmax in the control group at the time of observation was (min-max) 19.85 ml/sec (9-23.8), in the main group – 24 ml/sec (10-40) (p>0.05). CONCLUSIONS: The results of urethroplasty with the combined use of platelet-rich plasma in patients with recurrent urethral stricture demonstrate a decrease in the frequency of early relapses of urethral stricture, a reduction in the duration of bladder drainage and the frequency of infectious complications. Source of Funding: No source of funding. © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e972-e973 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sergey Kotov More articles by this author Mikhail Iritsyan More articles by this author Expand All Advertisement Loading ...