MP56-05 INTERREADER AGREEMENT IN MULTIPARAMETRIC MRI REPORTING USING PROSTATE IMAGING REPORTING AND DATA SYSTEM VERSION 2.1

Abstract

You have accessJournal of UrologyProstate Cancer: Detection & Screening IV (MP56)1 Apr 2020MP56-05 INTERREADER AGREEMENT IN MULTIPARAMETRIC MRI REPORTING USING PROSTATE IMAGING REPORTING AND DATA SYSTEM VERSION 2.1 Giorgio Brembilla*, Paolo Dell'Oglio, Armando Stabile, Anna Damascelli, Giulia Cristel, Silvia Ravelli, Antoinio Esposito, Alberto Briganti, Francesco Montorsi, and Francesco De Cobelli Giorgio Brembilla*Giorgio Brembilla* More articles by this author , Paolo Dell'OglioPaolo Dell'Oglio More articles by this author , Armando StabileArmando Stabile More articles by this author , Anna DamascelliAnna Damascelli More articles by this author , Giulia CristelGiulia Cristel More articles by this author , Silvia RavelliSilvia Ravelli More articles by this author , Antoinio EspositoAntoinio Esposito More articles by this author , Alberto BrigantiAlberto Briganti More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Francesco De CobelliFrancesco De Cobelli More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000925.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Prostate Imaging Reporting and Data System (PI-RADS) was introduced to standardize interpretation and reporting of prostate MRI across readers. However, prior studies reported only moderate reproducibility of PI-RADS, with poor to moderate agreement in lesion detection. The purpose of our study is to evaluate the agreement among readers with different expertise in detecting suspicious lesions at prostate multiparametric MRI using Prostate Imaging Reporting and Data System (PI-RADS) version 2.1. METHODS: We evaluated 200 consecutive biopsy naïve or previous negative biopsy men who underwent MRI for clinically suspected prostate cancer (PCa) between May and September 2017. Of them, 132 patients underwent prostate biopsy. Seven radiologists (four dedicated uro-radiologists and three non-dedicated abdominal radiologists) reviewed and scored all MRI examinations according to PI-RADS v2.1. Agreement on index lesion detection was evaluated with Conger’s k coefficient, agreement coefficient 1 (AC1), percentage of agreement (PA) and indexes of specific positive and negative agreement. Clinical and radiological features that may influence variability were evaluated. RESULTS: Agreement in index lesion detection among all readers was substantial (AC1: 0.738; 95%CI: 0.695-0.782); dedicated radiologists showed higher agreement compared to non-dedicated readers. Clinical and radiological parameters that positively influenced agreement were PSA density ≥0.15 ng/ml/cc, pre-MRI high risk for PCa, positivity threshold of PI-RADS score >3, PZ lesions, homogeneous signal intensity of the PZ and subjectively easy interpretation of MRI. Positive specific agreement was significantly higher among dedicated readers, up to 93.4% (95%CI: 90.7-95.4) in patients harboring csPCa. Agreement on absence of lesions was excellent for both dedicated and non-dedicated readers (respectively: 85.1% [95%CI 78.4-92.3]; and 82.0% [95%CI 77.2-90.1]). CONCLUSIONS: Agreement on index lesion detection among radiologists of various experience is substantial to excellent using PI-RADS v2.1. Concordance on absence of lesions is excellent across readers’ experience. Source of Funding: N/A © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e849-e849 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Giorgio Brembilla* More articles by this author Paolo Dell'Oglio More articles by this author Armando Stabile More articles by this author Anna Damascelli More articles by this author Giulia Cristel More articles by this author Silvia Ravelli More articles by this author Antoinio Esposito More articles by this author Alberto Briganti More articles by this author Francesco Montorsi More articles by this author Francesco De Cobelli More articles by this author Expand All Advertisement PDF downloadLoading ...