MP55-13 TESTICULAR TISSUE CRYOPRESERVATION FOR FERTILITY PRESERVATION PRIOR TO GONADOTOXIC THERAPY IN PEDIATRIC AND ADOLESCENT PATIENTS

Abstract

You have accessJournal of UrologyPediatric Urology V (MP55)1 Sep 2021MP55-13 TESTICULAR TISSUE CRYOPRESERVATION FOR FERTILITY PRESERVATION PRIOR TO GONADOTOXIC THERAPY IN PEDIATRIC AND ADOLESCENT PATIENTS Campbell Grant, Thomas Fitzgibbon, Marion Schulte, Brycen Ferrara, Olivia Frias, Abbey Riazzi, Michael Daugherty, Brian Vanderbrink, Paul Noh, William DeFoor, Eugene Minevich, Pramod Reddy, Karen Burns, Julie Rios, and Andrew Strine Campbell GrantCampbell Grant More articles by this author , Thomas FitzgibbonThomas Fitzgibbon More articles by this author , Marion SchulteMarion Schulte More articles by this author , Brycen FerraraBrycen Ferrara More articles by this author , Olivia FriasOlivia Frias More articles by this author , Abbey RiazziAbbey Riazzi More articles by this author , Michael DaughertyMichael Daugherty More articles by this author , Brian VanderbrinkBrian Vanderbrink More articles by this author , Paul NohPaul Noh More articles by this author , William DeFoorWilliam DeFoor More articles by this author , Eugene MinevichEugene Minevich More articles by this author , Pramod ReddyPramod Reddy More articles by this author , Karen BurnsKaren Burns More articles by this author , Julie RiosJulie Rios More articles by this author , and Andrew StrineAndrew Strine More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002085.13AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: With an improving survival of childhood cancers due to the advent of more effective multimodal therapies, the late effects on fertility have becoming increasingly important. Sperm cryopreservation (SCP) is the standard of care for fertility preservation (FP) in post-pubertal male patients. However, the options for FP are limited in pre-pubertal male patients and those who cannot provide a semen specimen. Testicular tissue cryopreservation (TTC) offers a promising, although still experimental, option for these patients. Our objectives were to review our experience with TTC and determine whether it impacted the time to therapy. METHODS: A retrospective cohort study was performed for male patients undergoing TTC in the Comprehensive Fertility Care and Preservation Program registry between April 2016 and December 2020. Risk assessment was based on the cumulative cyclophosphamide equivalent dose and stratified into low (<20% risk of permanent azoospermia), intermediate (20-80%), and high (>80%) risk. High-risk patients younger than 18 years of age and intermediate- or high-risk patients older than 18 years of age were eligible for TTC if they could not provide a semen specimen for SCP. TTC was combined with other surgical procedures whenever possible to minimize the anesthetic risk and expedite the initiation of therapy. RESULTS: A total of 280 patients were eligible during the study period, of which 67 (23.9%) elected for TTC. Median age (IQR) was 5.8 years (2.3-9). All patients were pre-pubertal and high-risk. A total of 33 (49.3%) patients were undergoing a bone marrow transplant for benign disease. Median (IQR) amount of testicular tissue harvested was 140.9 grams (71.2-193.6). There was malignant involvement of 1 (1.5%) testicular biopsy with acute lymphocytic leukemia. TTC was combined with other surgical procedures in 57 (85%) patients. Only 1 (1.5%) postoperative complication occurred, which was a scrotal hematoma that was managed non-operatively. A total of 31 patients with cancer underwent chemotherapy at our institution with a median (IQR) time from TTC to chemotherapy of 5 days (1-9). CONCLUSIONS: TTC was safe with minimal morbidity and no delay in the initiation of therapy in male patients with benign disease and cancer who would otherwise have no options for FP. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e963-e964 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Campbell Grant More articles by this author Thomas Fitzgibbon More articles by this author Marion Schulte More articles by this author Brycen Ferrara More articles by this author Olivia Frias More articles by this author Abbey Riazzi More articles by this author Michael Daugherty More articles by this author Brian Vanderbrink More articles by this author Paul Noh More articles by this author William DeFoor More articles by this author Eugene Minevich More articles by this author Pramod Reddy More articles by this author Karen Burns More articles by this author Julie Rios More articles by this author Andrew Strine More articles by this author Expand All Advertisement Loading ...