MP55-04 LOW SERUM INHIBIN B/FOLLICLE-STIMULATING HORMONE AND ANTI-MULLERIAN HORMONE/FOLLICLE-STIMULATING HORMONE RATIOS AS MARKERS OF DECREASED GERM CELLS IN INFANTS WITH BILATERAL CRYPTORCHIDISM

Abstract

You have accessJournal of UrologyPediatric Urology V (MP55)1 Sep 2021MP55-04 LOW SERUM INHIBIN B/FOLLICLE-STIMULATING HORMONE AND ANTI-MULLERIAN HORMONE/FOLLICLE-STIMULATING HORMONE RATIOS AS MARKERS OF DECREASED GERM CELLS IN INFANTS WITH BILATERAL CRYPTORCHIDISM Taiki Kato, Kentaro Mizuno, Hidenori Nishio, Akihiro Nakane, Satoshi Kurokawa, Hideyuki Kamisawa, Tetsuji Maruyama, Shoichiro Iwatsuki, Yukihiro Umemoto, Takahiro Yasui, and Yutaro Hayashi Taiki KatoTaiki Kato More articles by this author , Kentaro MizunoKentaro Mizuno More articles by this author , Hidenori NishioHidenori Nishio More articles by this author , Akihiro NakaneAkihiro Nakane More articles by this author , Satoshi KurokawaSatoshi Kurokawa More articles by this author , Hideyuki KamisawaHideyuki Kamisawa More articles by this author , Tetsuji MaruyamaTetsuji Maruyama More articles by this author , Shoichiro IwatsukiShoichiro Iwatsuki More articles by this author , Yukihiro UmemotoYukihiro Umemoto More articles by this author , Takahiro YasuiTakahiro Yasui More articles by this author , and Yutaro HayashiYutaro Hayashi More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002085.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: In cryptorchid boys, germ cell development failure occurs during infancy. Thus, the establishment of serum markers for predicting infertility is warranted. Serum inhibin B may reflect the state of the germinative epithelium. In this retrospective single-center observational study, we assessed the correlations between testicular histopathology and serum hormone levels according to testicular position in cryptorchid boys. METHODS: A total of 145 prepubertal boys underwent orchidopexy between December 2014 and May 2019 at our university hospital. Of them, 122 had unilateral cryptorchidism and 23 had bilateral cryptorchidism. Testicular biopsy was performed at orchidopexy. We examined the serum levels of inhibin B, anti-Mullerian hormone (AMH), gonadotropins, and testosterone; histological parameters; and the mean number of germ cells per seminiferous tubule cross-section (G/T). The area under the receiver operating characteristic (ROC) curve (AUC) showed the efficiency of each marker in predicting impaired germ cell numbers (below the lower limit of 0.4 G/T for boys without cryptorchidism). RESULTS: The mean G/T and serum inhibin B levels were significantly lower in the bilateral than in the unilateral cryptorchidism group (0.20 vs. 0.65, p<0.001; 96 [range 46–197] vs. 125 [range 21–354] pg/mL, p=0.026) (Table 1). Seven testes (4.1%) showed no germ cells (five boys with unilateral cryptorchidism and two boys with bilateral cryptorchidism). Inhibin B/follicle-stimulating hormone (FSH) and AMH/FSH ratios were correlated with the mean G/T in bilateral cryptorchid boys who were ≤24 months old at orchidopexy (n=12; p=0.008 and p=0.019, respectively). ROC curves showed significant correlations between impaired G/T and inhibin B/FSH (p=0.019, AUC 0.847) and AMH/FSH (p=0.004, AUC 0.932) ratios. CONCLUSIONS: In bilateral cryptorchid boys with a maximal age of 24 months, low inhibin B/FSH and AMH/FSH ratios may predict high risks for later infertility. Additional treatment and follow-up may be needed for such cases. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e959-e959 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Taiki Kato More articles by this author Kentaro Mizuno More articles by this author Hidenori Nishio More articles by this author Akihiro Nakane More articles by this author Satoshi Kurokawa More articles by this author Hideyuki Kamisawa More articles by this author Tetsuji Maruyama More articles by this author Shoichiro Iwatsuki More articles by this author Yukihiro Umemoto More articles by this author Takahiro Yasui More articles by this author Yutaro Hayashi More articles by this author Expand All Advertisement Loading ...