MP54-10 THE IMPACT OF OBESITY ON FEBRILE URINARY TRACT INFECTION AND RENAL SCARRING IN CHILDREN WITH VESICOURETERAL REFLUX

Abstract

You have accessJournal of UrologyPediatrics: Urinary Tract Infections/Vesicoureteral Reflux1 Apr 2015MP54-10 THE IMPACT OF OBESITY ON FEBRILE URINARY TRACT INFECTION AND RENAL SCARRING IN CHILDREN WITH VESICOURETERAL REFLUX Ji Yong Ha, Hye Jin Byun, Wonho Jung, Byung Hoon Kim, Chol Hee Park, Chun Il Kim, Kyung Seop Lee, and Jae Ho Kim Ji Yong HaJi Yong Ha More articles by this author , Hye Jin ByunHye Jin Byun More articles by this author , Wonho JungWonho Jung More articles by this author , Byung Hoon KimByung Hoon Kim More articles by this author , Chol Hee ParkChol Hee Park More articles by this author , Chun Il KimChun Il Kim More articles by this author , Kyung Seop LeeKyung Seop Lee More articles by this author , and Jae Ho KimJae Ho Kim More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2033AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Vesicoureteral reflux itself is an important cause of febrile urinary tract infection, but, various studies have been reported on the importance of other factors that cause urinary tract infections. In the adult, obesity is associated with body inflammatory response, increases the risk of a variety of infectious diseases, including the APN. Therefore, we evaluate the impact of obesity in children with vesicoureteral reflux. METHODS January 1992 to December 2008, from the 186 patients were diagnosed vesicoureteral reflux, we reviewed 72 patients with primary vesicoureteral reflux who had febrile urinary tract infection in hospitalized more than once. Patients, Based on WHO criteria, depending on the age-specific standard weight, were classified as Standard weight group (weight for age<85%), Overweight group (85%≤weight for age<95%), Obese group (weight for age ≥95%). And we compared the grade of vesicoureteral reflux, renal scars, surgery, degree of inflammation in febrile urinary tract infection according to BMI. RESULTS Of 72 patients, there were 41 in standard weight group, 16 in overweight group and 15 in obese group. There was no association with obesity and hydronephrosis, grade of reflux, surgery (p=0.563, 0.947, 0.313, respectively). However in overweight and obese group, VUR was diagnosed at a young age (p=0.05), the degrees of renal scars were more severe (p=0.006) and serum WBC count, CRP, ESR level was significantly higher (p<0.001, <0.001, <0.001, respectively). CONCLUSIONS In patients with vesicoureteral reflux, obesity have an effect in febrile urinary tract infection, renal scars and inflammatory reaction. Therefore, in obese patients, we should follow up more carefully and treat more aggrressively. Table 1. Characteristics of the patients with VUR according to obesity. Normal Overweight Obese P-Value No. of patients 41 16 15 - Mean age(Mo.) 13.2 10.7 7 0.05 Gender 0.12 Male 32 12 15 Female 9 4 0 Hydronephrosis grade 0.563 1 0 1 0 2 0 0 0 3 11 4 3 4 19 5 7 5 11 6 5 Reflux grade 0.947 3 9 3 2 4 21 7 8 5 11 6 5 Laboratory findings WBC count(/mm³) 13136 20104 23858 <0.001 ESR(mm/h) 8.7 29.4 33.3 <0.001 CRP(mg/dL) 3.4 11.0 13.5 <0.001 Surgical treatment 0.313 Yes 32 14 10 No 9 2 5 Renal scarring 0.006 Absent 33 7 7 Present Focal 5 8 4 Multiple 3 1 3 © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e668-e669 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Ji Yong Ha More articles by this author Hye Jin Byun More articles by this author Wonho Jung More articles by this author Byung Hoon Kim More articles by this author Chol Hee Park More articles by this author Chun Il Kim More articles by this author Kyung Seop Lee More articles by this author Jae Ho Kim More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...