MP54-16 FAVORABLE PROGNOSIS IN END-STAGE RENAL DISEASE PATIENTS WITH RENAL CELL CARCINOMA: A LONG-TERM FOLLOW-UP STUDY IN A SINGLE INSTITUTION

Abstract

You have accessJournal of UrologyKidney Cancer: Localized III1 Apr 2014MP54-16 FAVORABLE PROGNOSIS IN END-STAGE RENAL DISEASE PATIENTS WITH RENAL CELL CARCINOMA: A LONG-TERM FOLLOW-UP STUDY IN A SINGLE INSTITUTION Yoshihiro Ikeda, Yoshio Terasawa, Shinichi Yamashita, Takashi Kudo, Masataka Aizawa, Hisanobu Adachi, Mareyuki Endo, Kensuke Joh, Naomasa Ioritani, and Seiichi Orikasa Yoshihiro IkedaYoshihiro Ikeda More articles by this author , Yoshio TerasawaYoshio Terasawa More articles by this author , Shinichi YamashitaShinichi Yamashita More articles by this author , Takashi KudoTakashi Kudo More articles by this author , Masataka AizawaMasataka Aizawa More articles by this author , Hisanobu AdachiHisanobu Adachi More articles by this author , Mareyuki EndoMareyuki Endo More articles by this author , Kensuke JohKensuke Joh More articles by this author , Naomasa IoritaniNaomasa Ioritani More articles by this author , and Seiichi OrikasaSeiichi Orikasa More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1605AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail Introduction and Objectives Patients with end-stage renal disease (ESRD) show an increased risk of renal cell carcinoma (RCC). Some recent reports have revealed better prognosis for ESRD-RCC than for sporadic RCC. We have achieved successful long-term results for RCC patients with ESRD, and evaluated clinical characteristics and oncological outcomes of ESRD-RCC in this study. Methods From November 1985 to January 2013, 187 male and 33 female patients with ESRD-RCC underwent radical nephrectomy in our institute. All patients showed a dialysis status of chronic renal failure at the time of diagnosis. Information about age, sex, symptoms, duration of dialysis therapy, tumor staging and grading, histological subtype and outcome were recorded. Survival was assessed using Kaplan-Meier methods. Results Symptomatic RCC was only seen in 22 cases (10.0%), and gross hematuria was the most frequent complaint (13 cases). Incidental cases comprised 198 (90.0%), with 152 cases (88.2%) diagnosed on routine screening ultrasonography. Radical nephrectomy was performed in 270 cases, and mean age at operation was 55.0}11.0 years. Bilateral RCC was observed in 54 patients (24.5%). Mean duration of dialysis before surgery was 154.1}92.5 months, and mean follow-up period was 90.0}71.9 months. Pathological tumor stage was stage 1 in 265 kidneys (98.1%), and mean maximum tumor size was 2.2}1.3 cm. Eight patients showed advanced RCC, and 1 patient died from renal cancer. Twenty-two patients died from other causes. Estimated 5- and 10-year cancer-specific survival rates were both 99.6%. Five- and 10-year recurrence-free survival rates were 95.5% and 94.8%, respectively. Conclusions RCC arising in native kidneys of dialyzed patients seems to show favorable outcomes. In our institute, most ESRD patients were identified under routine screening ultrasonography and detected in the early stage with small diameter RCC. Careful and regular screening ultrasonography seems important for better survival of ESRD patients with RCC. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e578 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Yoshihiro Ikeda More articles by this author Yoshio Terasawa More articles by this author Shinichi Yamashita More articles by this author Takashi Kudo More articles by this author Masataka Aizawa More articles by this author Hisanobu Adachi More articles by this author Mareyuki Endo More articles by this author Kensuke Joh More articles by this author Naomasa Ioritani More articles by this author Seiichi Orikasa More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...