MP53-14 VITAMIN D DEFICIENCY PREDICTS ADVERSE PATHOLOGY AT TIME OF RADICAL PROSTATECTOMY

Abstract

You have accessJournal of UrologyProstate Cancer: Staging I1 Apr 2015MP53-14 VITAMIN D DEFICIENCY PREDICTS ADVERSE PATHOLOGY AT TIME OF RADICAL PROSTATECTOMY Diana K. Bowen, Gregory A. Jordan, Tyler J. Maiers, Rick A. Kittles, and Adam B. Murphy Diana K. BowenDiana K. Bowen More articles by this author , Gregory A. JordanGregory A. Jordan More articles by this author , Tyler J. MaiersTyler J. Maiers More articles by this author , Rick A. KittlesRick A. Kittles More articles by this author , and Adam B. MurphyAdam B. Murphy More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1708AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Recently vitamin D has been associated with increased odds of prostate cancer (PCa) diagnosis in African American (AA) men and advanced PCa in European American (EA) and AA men. We examine the relationship between serum vitamin D levels in men who underwent radical prostatectomy (RP) and the presence of adverse pathology. METHODS Serum 25-hydroxyvitamin D (25-OH D) was obtained from 199 PCa patients at the time of prostate biopsy who underwent RP within 1 year in Chicago, Illinois. Adverse pathology at the time of RP was defined by the presence of dominant Gleason pattern 4, the presence of any pattern 5, and pathologic stage ≥ pT3a. Descriptive statistics were used to characterize important covariates including age, race, body mass index (BMI), alcohol & smoking use, income, PCa family history, marital status, education, 5 alpha-reductase inhibitor use, and season. Season was defined based on UV exposure data. Cut points for 25-OH D deficiency were based on sensitivity analysis. Binary logistic regression was used to evaluate the association of 25-OH D and adverse pathology. RESULTS Table 1 displays characteristics of the adverse vs. non-adverse pathology groups. On univariate analysis, adverse pathology was correlated with age (r=0.15; p=0.03), PSA (r=0.21;p=0.003), obesity (r=0.19; p=0.007) and a 25-OH D level less than 30ng/mL (r=0.16; p=0.03). Race, alcohol use, smoking status, income, level of education, PCa family history and season were not correlated with the presence of adverse pathology. On regression, age (OR 1.05; p=0.047), obesity (OR 2.39; p = 0.01), and 25-OH D < 30 ng/mL (OR 2.20; p=0.04) were associated with increased odds of adverse pathology. Smoking, season, and race were not statistically significant. CONCLUSIONS Serum vitamin D deficiency is associated with increased odds of adverse pathology on RP. The mechanisms underlying this association deserve further exploration. Table 1. Characteristics of men with and without adverse pathology at the time of radical prostatectomy. Continuous Variables Non-Adverse Pathology (N=128) N (SD) Adverse Pathology (N=71) N (SD) P-Value Age, years 60.6 (6.6) 62.7 (6.9) 0.03† BMI, kg/m2 27.0 (6.3) 28.2 (7.9) 0.24 PSA at diagnosis, ng/mL 5.7 (3.3) 35.8 (111.7) 0.03† 25-OH D, ng/mL 24.0 (10.3) 22.0 (9.3) 0.18 Income, US $ $49,200 ($26,700) $44,900 ($26,140) 0.27 Categorical Variables Non-Adverse Pathology N (%) Adverse Pathology N (%) P-Value Obesity (BMI > 30 kg/m2 25 (19.8%) 26 (37.7%) 0.007† Married, (yes/no) 94 (73.4%) 55 (77.5%) 0.53 1st degree PCa Family History 35 (28.0%) 17 (25.8%) 0.74 25-OH D < 30 ng/mL 88 (68.8%) 59 (83.1%) 0.03† 25-OH D < 20 ng/mL 41 (32.0%) 27 (38.0%) 0.39 Smoking History (ever/never) 63 (49.2%) 33 (46.5%) 0.71 Alcohol Use (ever/never) 119 (93.0%) 63 (88.7%) 0.31 Black Racial Status (yes/no) 90 (70.3%) 50 (70.4%) 0.99 5-alpha Reductase Inhibitor Use (yes/no) 7 (5.5%) 3 (4.2%) 0.7 High UV Season 64.0 (50.0%) 36 (50.7%) 0.92 † Denotes p< 0.05; High UV season was defined by the months of May through October based on reported average ultraviolet radiation exposure in Chicago, Illinois. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e641 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Diana K. Bowen More articles by this author Gregory A. Jordan More articles by this author Tyler J. Maiers More articles by this author Rick A. Kittles More articles by this author Adam B. Murphy More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...