MP53-04 RECOVERY OF SEXUAL FUNCTION IN MEN TREATED WITH ANDROGEN DEPRIVATION THERAPY FOR LOCALIZED PROSTATE CANCER

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Radiation Therapy (MP53)1 Apr 2020MP53-04 RECOVERY OF SEXUAL FUNCTION IN MEN TREATED WITH ANDROGEN DEPRIVATION THERAPY FOR LOCALIZED PROSTATE CANCER Daniel D. Joyce*, Amy N. Luckenbaugh, Heather L. Huelster, Zighuo Zhao, Karen E. Hoffman, Li-Ching Huang, Tatsuki Koyama, Ralph Conwill, David F. Penson, and Daniel A. Barocas Daniel D. Joyce*Daniel D. Joyce* More articles by this author , Amy N. LuckenbaughAmy N. Luckenbaugh More articles by this author , Heather L. HuelsterHeather L. Huelster More articles by this author , Zighuo ZhaoZighuo Zhao More articles by this author , Karen E. HoffmanKaren E. Hoffman More articles by this author , Li-Ching HuangLi-Ching Huang More articles by this author , Tatsuki KoyamaTatsuki Koyama More articles by this author , Ralph ConwillRalph Conwill More articles by this author , David F. PensonDavid F. Penson More articles by this author , and Daniel A. BarocasDaniel A. Barocas More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000915.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Decreased sexual function during androgen deprivation therapy (ADT) is well described; however, limited data exist regarding sexual function recovery following ADT use in treatment of localized prostate cancer. In this study, we compared sexual function in men who received ADT plus external beam radiation treatment (EBRT) to EBRT alone and identified patient-level predictors of sexual function recovery. METHODS: We prospectively enrolled a population-based cohort of men who underwent EBRT with and without ADT for intermediate- or high-risk localized prostate cancer as part of the Comparative Effectiveness Analysis of Surgery and Radiation study. Sexual function was assessed longitudinally out to 5 years using the validated Expanded Prostate Cancer Index Composite survey. Sexual and hormone domain scores range from 0 (worst) to 100 (best) points. Men with erections sufficient for intercourse at baseline were selected for inclusion. Patients still receiving ADT at 5 years were excluded from analysis. RESULTS: A total of 167 patients were included. Of these, 73 underwent EBRT alone and 94 received ADT plus EBRT (51 with intermediate-risk and 43 with high-risk disease). Baseline sexual function was similar between groups (p=0.218). Compared to EBRT alone, ADT in high-risk disease was associated with worse sexual function at 3 years (Effect: -20.3 points, CI -31.8, -8.8, p<0.001) but not at 5 years (Effect: -3.4 points, CI -17.2, 10.5, p=0.633). Neither baseline function, age, nor cardiovascular health influenced receipt of ADT. CONCLUSIONS: ADT plus EBRT is associated with worse sexual function through 3-years follow-up in men with high-risk prostate cancer compared to EBRT alone. The addition of ADT in treatment of intermediate-risk disease does not appear to result in worse sexual function at 3 or 5-year follow-up compared to EBRT alone. Source of Funding: This study was supported by the Agency for Healthcare Research and Quality (1R01HS019356, 1R01HS022640) and the Patient-Centered Outcomes Research Institute (CE-12-11-4667). Data management was facilitated by Vanderbilt University’s Research Electronic Data Capture (REDCap) system, which is supported by the Vanderbilt Institute for Clinical and Translational Research grant (UL1TR000011 from NCATS/NIH). © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e782-e783 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Daniel D. Joyce* More articles by this author Amy N. Luckenbaugh More articles by this author Heather L. Huelster More articles by this author Zighuo Zhao More articles by this author Karen E. Hoffman More articles by this author Li-Ching Huang More articles by this author Tatsuki Koyama More articles by this author Ralph Conwill More articles by this author David F. Penson More articles by this author Daniel A. Barocas More articles by this author Expand All Advertisement PDF downloadLoading ...