MP53-03 ASSESSING RACIAL DISPARITIES IN LOW AND FAVORABLE INTERMEDIATE RISK PROSTATE CANCER PATIENTS OVER A 27-YEAR PERIOD TREATED WITH EXTERNAL BEAM RADIATION THERAPY IN A RACIALLY DIVERSE, EQUAL ACCESS MILITARY HEALTHCARE SYSTEM

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Radiation Therapy (MP53)1 Apr 2020MP53-03 ASSESSING RACIAL DISPARITIES IN LOW AND FAVORABLE INTERMEDIATE RISK PROSTATE CANCER PATIENTS OVER A 27-YEAR PERIOD TREATED WITH EXTERNAL BEAM RADIATION THERAPY IN A RACIALLY DIVERSE, EQUAL ACCESS MILITARY HEALTHCARE SYSTEM Sean Stroup*, Audry Robertson, Kayla Onofaro, Michael Santomauro, Nicholas Rocco, Huai-ching Kuo, Avinash Chaurasia, Inger Rosner, Timothy Brand, John Musser, Christopher Porter, Grace Lu-Yao, Anthony D'Amico, and Jennifer Cullen Sean Stroup*Sean Stroup* More articles by this author , Audry RobertsonAudry Robertson More articles by this author , Kayla OnofaroKayla Onofaro More articles by this author , Michael SantomauroMichael Santomauro More articles by this author , Nicholas RoccoNicholas Rocco More articles by this author , Huai-ching KuoHuai-ching Kuo More articles by this author , Avinash ChaurasiaAvinash Chaurasia More articles by this author , Inger RosnerInger Rosner More articles by this author , Timothy BrandTimothy Brand More articles by this author , John MusserJohn Musser More articles by this author , Christopher PorterChristopher Porter More articles by this author , Grace Lu-YaoGrace Lu-Yao More articles by this author , Anthony D'AmicoAnthony D'Amico More articles by this author , and Jennifer CullenJennifer Cullen More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000915.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Racial disparities in prostate cancer health outcomes, especially among African American men, continue to be a significant national concern. We evaluated longitudinal cancer-related outcomes in the context of racial disparities for patients with low and favorable-intermediate risk PCa treated with primary external beam radiotherapy (EBRT). METHODS: Patients consented and enrolled into the Center for Prostate Disease Research Multicenter National Database and diagnosed with low and favorable-intermediate PCa between 1990 and 2017 and treated with EBRT were eligible. Clinical and pathologic factors were compared between African American (AA) and Caucasian American (CA) men. Biochemical recurrence (BCR)-free, distant metastasis (DM)-free, and overall survival probability estimates were computed using Unadjusted Kaplan-Meier (KM) estimation curve analysis and multivariable Cox proportional hazards (PH) analysis, controlling for key study covariates.KM curves were also used to analyze prostate specific antigen (PSA) doubling time (PSADT) within each racial group for those that developed DM. RESULTS: Of the 840 men included in this study, 268 (32%) were AA and 572 (68%) were CA. Median age at time of EBRT was significantly different between racial groups with AA men being treated at a younger age. AA men were more likely to have a higher biopsy-detected Gleason Score compared to CA men. Unadjusted KM estimation curves demonstrated no differences between races when looking at probability of BCR-free, DM-free, and overall survival over time. Multivariable Cox PH analyses revealed no significant differences between AA and CA men when assessing survival time from radiation therapy (RT) to BCR (AHR=1.2, 95% CI=0.6-2.7, P=0.586), RT to DM (AHR=2.3, 95% CI=0.6-9, P=0.242) and RT to overall death (AHR=1.3, 95% CI=0.8-2, P=0.305). CONCLUSIONS: In an equal access healthcare system, over a 27-year period there were no significant racial differences in BCR-related, DM-related, and overall death-related outcomes for AA compared to CA men. Access to and receipt of healthcare appears to reduce disparities in outcomes in the military setting. Source of Funding: DOD CDMRP Health Disparities Award # W81XWH-15-1-0381. Disclaimers: The opinions or assertions contained herein are the private ones of the author/speaker and are not to be construed as official or reflecting the views of the Department of Defense, the Uniformed Services University of the Health Sciences or any other agency of the U.S. Government. © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e782-e782 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Sean Stroup* More articles by this author Audry Robertson More articles by this author Kayla Onofaro More articles by this author Michael Santomauro More articles by this author Nicholas Rocco More articles by this author Huai-ching Kuo More articles by this author Avinash Chaurasia More articles by this author Inger Rosner More articles by this author Timothy Brand More articles by this author John Musser More articles by this author Christopher Porter More articles by this author Grace Lu-Yao More articles by this author Anthony D'Amico More articles by this author Jennifer Cullen More articles by this author Expand All Advertisement PDF downloadLoading ...