MP53-02 NEGATIVE PREDICTIVE VALUE OF A NEGATIVE MULTI-PARAMETRIC MRI OF PROSTATE

Abstract

You have accessJournal of UrologyProstate Cancer: Detection & Screening VII1 Apr 2016MP53-02 NEGATIVE PREDICTIVE VALUE OF A NEGATIVE MULTI-PARAMETRIC MRI OF PROSTATE Joseph Mahon, Ronald P Kaufman Jr., Rebecca O'Malley, Badar Mian, Hugh Fisher, and Ahmed Essa Joseph MahonJoseph Mahon More articles by this author , Ronald P Kaufman Jr.Ronald P Kaufman Jr. More articles by this author , Rebecca O'MalleyRebecca O'Malley More articles by this author , Badar MianBadar Mian More articles by this author , Hugh FisherHugh Fisher More articles by this author , and Ahmed EssaAhmed Essa More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.499AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES A significant number of men with clinical indications for prostate biopsy are found to have no evidence of disease on multi-parametric MRI (MP-MRI) of prostate. We sought to determine the prostate biopsy results in this cohort of men to further elucidate the negative predictive value of MP-MRI in the setting of clinical suspicion of prostate cancer. METHODS We reviewed the records of 395 men with clinical suspicion for prostate cancer who underwent MP-MRI of prostate prior to the biopsy. Men without any lesions on the MRI or lesions graded PiRADS 1-2 were included in the benign or the MRI negative group. We identified 169 (43%) men with negative pre-biopsy MRI of prostate. Clinical and demographic data were recorded. Mean PSA was 5.6 ng/ml and 69% had normal DRE. These men with clinical suspicious of prostate cancer but a negative MRI underwent random systematic (12-core) biopsy procedure. RESULTS Of the 169 men with negative pre-biopsy MP-MRI of prostate, 124 (73%) were biopsy-naive while 45 (27%) had previous biopsy. Overall, prostate cancer was noted in 54 (32%) men. Among biopsy-naive men 44 (35%) had cancer on their first biopsy, while 10 (22%) of those with a previous biopsy had cancer. Overall, mean number of positives cores was 2.3 (range 1-10). Among the men with cancer, 47 (88%) had Gleason score 6 or uni-focal Gleason 3+4. Predominant pattern 4+3 in 10% and 4+4 was noted in 2%, all of whom were biopsy-naive men. CONCLUSIONS Negative MP-MRI of prostate has high negative predictive value to rule out high risk or multi-focal intermediate risk prostate cancer. These findings may allow us to give patients the option to omit or postpone the prostate biopsy. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e697 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Joseph Mahon More articles by this author Ronald P Kaufman Jr. More articles by this author Rebecca O'Malley More articles by this author Badar Mian More articles by this author Hugh Fisher More articles by this author Ahmed Essa More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...