MP53-19 GENETIC BASIS FOR A GREATER PROGRESSION RATE TO A HIGHER GRADE OF LOW RISK PROSTATE CANCER AMONG AFRICAN AMERICANS COMPARED TO EUROPEAN AMERICANS: IMPACT ON ACTIVE SURVEILLANCE RECOMMENDATIONS.

Abstract

You have accessJournal of UrologyProstate Cancer: Staging I1 Apr 2015MP53-19 GENETIC BASIS FOR A GREATER PROGRESSION RATE TO A HIGHER GRADE OF LOW RISK PROSTATE CANCER AMONG AFRICAN AMERICANS COMPARED TO EUROPEAN AMERICANS: IMPACT ON ACTIVE SURVEILLANCE RECOMMENDATIONS. Isaac Powell, Greg Dyson, and Aliccia Bollig-Fischer Isaac PowellIsaac Powell More articles by this author , Greg DysonGreg Dyson More articles by this author , and Aliccia Bollig-FischerAliccia Bollig-Fischer More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1713AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES It has been reported that there is a 2 to 3 fold increase to higher grade PCa of men diagnosed with low risk prostate cancer (PCa) among African American men (AAM) compared to European American men (EAM). Recently, it has been reported that biochemical recurrence is similar among low risk AAM and intermediate risk EAM followed for 20 years. (in press) We have extensively studied gene expression using microarray analysis among AAM and EAM and have identified a genetic/biologic basis for these findings. METHODS The objective was to evaluate the expression of three genes (CXCR4, IL6 and IL8) with known implications related to prostate cancer in AAM and EAM. Aggressive prostate cancer is defined as having a BCR event within 3 years, a GS upon RP greater than or equal to 7 (4+3) and T3 disease. Non-aggressive disease is defined as being BCR-free after 5 years post RP, a GS upon RP less than or equal to 6 and T1-T2 disease. We log transformed the gene expression values and excluded any gene expression value outside of 4 standard deviations from the mean value to avoid issues with outliers. We focus our analysis on the comparison of gene expression of the AAM/non-aggressive group to the EAM/aggressive group; evaluated using a t-test assuming unequal variance between the two groups. RESULTS The expression of CXCR4 was not significantly different (fold change [FC] of AAM relative to EAM = 0.99, p=0.84) between AAM/non-aggressive group to the EAM/aggressive group. The expression of IL6 was significantly higher (FC=1.36, p=0.005) in the AAM/non-aggressive group as compared to the EAM/aggressive group. The expression of IL8 was significantly higher (FC=1.16, p=0.05) in the AAM/non-aggressive group as compared to the EAM/aggressive group. CONCLUSIONS The expression of IL8, IL6 and CXCR4 are associated with advanced PCa. When stratified by race and aggressive vs non-aggressive disease, the expression of these genes among AAM diagnosed with low risk PCa and EAM diagnosed with high risk PCa are similar or higher for AAM. Therefore AAM should be followed very cautiously and perhaps recommendations should be different for AAM vs EAM diagnosed with low risk PCa and eligible for active surveillance. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e643 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Isaac Powell More articles by this author Greg Dyson More articles by this author Aliccia Bollig-Fischer More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...