MP53-04 PEDIATRIC UROTHELIAL CANCER SURVIVAL OUTCOMES: ANALYSIS OF THE NATIONAL CANCER DATABASE

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP53-04 PEDIATRIC UROTHELIAL CANCER SURVIVAL OUTCOMES: ANALYSIS OF THE NATIONAL CANCER DATABASE Rafael Tua-Caraccia, Leonid Aksenov, Rebecca Fairchild, Kristen Rhodin, Harold Leeras, Elisabeth Tracy, and Jonathan Routh Rafael Tua-CaracciaRafael Tua-Caraccia More articles by this author , Leonid AksenovLeonid Aksenov More articles by this author , Rebecca FairchildRebecca Fairchild More articles by this author , Kristen RhodinKristen Rhodin More articles by this author , Harold LeerasHarold Leeras More articles by this author , Elisabeth TracyElisabeth Tracy More articles by this author , and Jonathan RouthJonathan Routh More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003301.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Urothelial cancer is a rare malignancy among children and adolescents. Studies examining outcomes in this condition suggest low rate of recurrence or death compared to adults. We therefore assessed pediatric urothelial cancer outcomes, which we hypothesize to be favorable. METHODS: We analyzed the 2004-2016 National Cancer DataBase (NCDB). The population of interest was pediatric patients (0-18 yrs) with a diagnosis of urothelial cancer of bladder. Those with rhabdomyosarcoma were excluded. Variables of interest included TNM staging, pathology, tumor size, surgical procedures, and post-operative re-admission. Overall survival was defined as months since diagnosis as of last follow-up. Descriptive statistics were used to represent sample demographics, histology, and staging. Categorical variables were presented as frequencies; continuous variables as means with standard deviations. RESULTS: Of the 140 cases of predominantly papillary urothelial neoplasm of low malignant potential reported to NCDB between 2004-2016, 75.7% (N=106) were Stage 0 at time of diagnosis, 6.4% (N=9) were stage I, 2.9% (N=4) were Stage II and 3.6% (N=5) were Stage IV while 11.4% cases (N=16) were unknown. From available mortality data on 121 of 140 patient records, 30-day mortality was zero; no patients died after definitive surgical resection of the primary site or date of first surgical procedure. Only 1 of 121 patient was reported as dead at 90 days, although cause of death is unknown. Most (96.7%) were alive at 90 days and 3 (2.5%) were lost to follow-up. CONCLUSIONS: We report reassuring short term outcomes among children and adolescents diagnosed with non-rhabdomyosarcoma bladder tumors while illuminating the need for further data to characterize long-term outcomes, specifically recurrence and quality of life. This informs patient counseling and questions whether adult protocols for low-risk, non-muscle-invasive, bladder cancer surveillance are appropriate in children, particularly given the need for general anesthesia for cystoscopic surveillance. We suggest that such surveillance techniques may not best serve the long-term outcomes of these patients, and simple monitoring with renal/bladder ultrasound may be a more effective and efficient surveillance option. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e713 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Rafael Tua-Caraccia More articles by this author Leonid Aksenov More articles by this author Rebecca Fairchild More articles by this author Kristen Rhodin More articles by this author Harold Leeras More articles by this author Elisabeth Tracy More articles by this author Jonathan Routh More articles by this author Expand All Advertisement PDF downloadLoading ...