MP51-17 ORGASMIC FUNCTION RELIES ON TESTOSTERONE LEVELS - RESULTS OF A CROSS-SECTIONAL STUDY IN MEN SEEKING MEDICAL HELP FOR ERECTILE DYSFUNCTION

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation II1 Apr 2015MP51-17 ORGASMIC FUNCTION RELIES ON TESTOSTERONE LEVELS - RESULTS OF A CROSS-SECTIONAL STUDY IN MEN SEEKING MEDICAL HELP FOR ERECTILE DYSFUNCTION Eugenio Ventimiglia, Paolo Capogrosso, Luca Boeri, Alessandro Serino, Giovanni La Croce, Giulia Castagna, Angela Pecoraro, Marco Paciotti, Roberta Scano, Dana Kuefner, Rocco Damiano, Francesco Montorsi, and Andrea Salonia Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Paolo CapogrossoPaolo Capogrosso More articles by this author , Luca BoeriLuca Boeri More articles by this author , Alessandro SerinoAlessandro Serino More articles by this author , Giovanni La CroceGiovanni La Croce More articles by this author , Giulia CastagnaGiulia Castagna More articles by this author , Angela PecoraroAngela Pecoraro More articles by this author , Marco PaciottiMarco Paciotti More articles by this author , Roberta ScanoRoberta Scano More articles by this author , Dana KuefnerDana Kuefner More articles by this author , Rocco DamianoRocco Damiano More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea SaloniaAndrea Salonia More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1754AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Testosterone supplementation plays positive effects on male sexual function in hypogonadal individuals. Conversely, the role of testosterone supplementation is uncertain in men who are not clearly hypogonadal. We sought to investigate clinical predictors of orgasmic functioning (OF) in a cohort of patients seeking medical help for erectile dysfunction (ED) in the real-life setting. METHODS Complete sociodemographic and clinical data from the last 410 patients with ED were analysed. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI). All patients completed the International Index of Erectile Function (IIEF) domains. Normality of the IIEF-OF domain was arbitrarily defined for values < the median. Likewise, patients completed the Male Sexual Health Questionnaire (MSHQ). Serum total testosterone (tT) was dosed in all cases. Hypogonadism was defined as tT <3 ng/ml. Descriptive statistics and either logistic or linear regression analyses tested the association between clinical variables and OF. RESULTS The mean (median) IIEF-OF value of the cohort was 6.9 (8.0). Overall, 182 (44.4%) patients had IIEF-OF scores below the median; of these, one out of four patients was ≤40 years. The mean (median) tT value was 4.7 (4.5) ng/mL. Hypogonadism was found in 81 (19.8%) patients. Patients with abnormal IIEF-OF were older [mean (SD): 47.4 (13.0) vs. 50.1 (15.4) years; p<0.01] and had a higher CCI [mean (SD): 0.42 (0.9) vs. 0.63 (1.0); p=0.003]. At multivariable linear regression analyses, IIEF-OF linearly decreased with tT values (β 0.195; p=0.027) and MSHQ-EF scores (β 0.36; p<0.001), after accounting for the patient's age and CCI. At multivariable logistic regression analyses, hypogonadism (OR 3.99; p=0.007) and MSHQ-EF scores (OR 0.86; p=0.004) achieved independent predictor status for abnormal IIEF-OF, after accounting for patient age and CCI. CONCLUSIONS This exploratory analysis showed that impaired OF is highly frequent in individuals seeking medical help for ED in the real-life setting, with one in four patients being young men. IIEF-OF linearly decreased with tT values and EF scores. Likewise, hypogonadism and MSHQ-EF scores achieved independent predictor status for abnormal IIEF-OF. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e626 Peer Review Report Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Eugenio Ventimiglia More articles by this author Paolo Capogrosso More articles by this author Luca Boeri More articles by this author Alessandro Serino More articles by this author Giovanni La Croce More articles by this author Giulia Castagna More articles by this author Angela Pecoraro More articles by this author Marco Paciotti More articles by this author Roberta Scano More articles by this author Dana Kuefner More articles by this author Rocco Damiano More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...