MP50-20 INCREASED THYROID CANCER RISK IN PATIENTS WITH KIDNEY CANCERS

Abstract

You have accessJournal of UrologyKidney Cancer: Evaluation and Staging III1 Apr 2015MP50-20 INCREASED THYROID CANCER RISK IN PATIENTS WITH KIDNEY CANCERS Emrullah Yilmaz, Tejas Suresh, Benjamin Gartrell, Ashutossh Naaraayan, Antonio Di Cristofano, Eric Epstein, Howard Strickler, Marston Linehan, Steven Libutti, Missak Haigentz, and Reza Ghavamian Emrullah YilmazEmrullah Yilmaz More articles by this author , Tejas SureshTejas Suresh More articles by this author , Benjamin GartrellBenjamin Gartrell More articles by this author , Ashutossh NaaraayanAshutossh Naaraayan More articles by this author , Antonio Di CristofanoAntonio Di Cristofano More articles by this author , Eric EpsteinEric Epstein More articles by this author , Howard StricklerHoward Strickler More articles by this author , Marston LinehanMarston Linehan More articles by this author , Steven LibuttiSteven Libutti More articles by this author , Missak HaigentzMissak Haigentz More articles by this author , and Reza GhavamianReza Ghavamian More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.2931AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Recent reports of population-based data suggest bidirectional increased risk of thyroid cancers in patients with a history of kidney cancer, predominantly in Caucasian populations. We sought to evaluate this association and identify clinical and pathological characteristics of these patients in a large urban, inner city medical center. METHODS We reviewed our cancer registry data from 2000 to 2013 for patients diagnosed with kidney and prostate cancer. We identified patients who had a primary thyroid cancer diagnosed at any point using ICD-9 codes and reviewed their clinical records. We compared this potential association within the genitourinary cancer cohort. As prostate cancer is the most common genitourinary cancer, we compared the association of thyroid cancer with kidney cancer to that of thyroid cancer with prostate cancer. RESULTS A total of 1374 kidney and 5874 prostate cancers were diagnosed during this 14-year interval, and a total of 18 patients had thyroid cancers (10 kidney; 8 prostate). We observed 5.3-fold increased risk of thyroid cancer in patients with kidney cancer over prostate cancer (p<0.0001, χ2=21.864), which persisted when limiting the analysis to men (see table). Of the 10 patients with kidney cancer, histologic types included clear cell carcinoma in 4, papillary and clear cell histology in 2, papillary in 1, sarcomatous in 1, and unknown in 2. Thyroid cancer histologies included papillary (3/10), follicular (2/10) and anaplastic carcinoma (1/10) and unknown in (5/10). Notably, all patients with papillary thyroid cancers (3/10), had distant metastasis. The ethnicities of the patients with kidney and thyroid cancer were Caucasian (5/10), Black (3/10) and other (2/10). The longest interval between the diagnoses of the two cancers was 137 months. CONCLUSIONS We observed a significant risk for thyroid cancer among patients with a history of kidney cancer. Interestingly, these thyroid malignancies appeared more clinically aggressive than typical reports of well differentiated thyroid cancer. Further investigation of this association is warranted. Kidney cancer∗ Prostate cancer∗ Chi square p-value Males with thyroid cancer 5 (817) 8 (5874) 21.864 <0.0001 Females with thyroid cancer 5 (557) - Total with thyroid cancer 10 (1374) 8 (5874) 28.454 <0.0001 ∗ Total number of pts in parentheses © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e618-e619 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Emrullah Yilmaz More articles by this author Tejas Suresh More articles by this author Benjamin Gartrell More articles by this author Ashutossh Naaraayan More articles by this author Antonio Di Cristofano More articles by this author Eric Epstein More articles by this author Howard Strickler More articles by this author Marston Linehan More articles by this author Steven Libutti More articles by this author Missak Haigentz More articles by this author Reza Ghavamian More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...