MP50-15 QUANTIFYING THE PROBABILITY OF NEEDING SALVAGE RADIOTHERAPY FOLLOWING ROBOTIC PROSTATECTOMY: STRATIFICATION USING PROSPECTIVE CLINICAL, RADIOLOGICAL AND PATHOLOGICAL DATA

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy III (MP50)1 Sep 2021MP50-15 QUANTIFYING THE PROBABILITY OF NEEDING SALVAGE RADIOTHERAPY FOLLOWING ROBOTIC PROSTATECTOMY: STRATIFICATION USING PROSPECTIVE CLINICAL, RADIOLOGICAL AND PATHOLOGICAL DATA John Withington, Alice Russell, Tom Cahill, Bradley Russell, Julia Murray, Chris Parker, Simon Hughes, Steve Hazell, Netty Kinsella, and Declan Cahill John WithingtonJohn Withington More articles by this author , Alice RussellAlice Russell More articles by this author , Tom CahillTom Cahill More articles by this author , Bradley RussellBradley Russell More articles by this author , Julia MurrayJulia Murray More articles by this author , Chris ParkerChris Parker More articles by this author , Simon HughesSimon Hughes More articles by this author , Steve HazellSteve Hazell More articles by this author , Netty KinsellaNetty Kinsella More articles by this author , and Declan CahillDeclan Cahill More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002076.15AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Robotic radical prostatectomy (RARP) is a standalone therapeutic modality, with the need for salvage radiotherapy often treated as an unpredictable setback. In fact it’s an added therapeutic factor. We analysed prospectively collected clinical, radiological and pathological data from a single surgeon series of RARPs. METHODS: Data from patients undergoing RARP between 2015 and 2020, with a minimum of 12 months’ follow up were analysed. Descriptive statistical analysis was conducted, and relative risk was calculated for selected variables of interest. RESULTS: 802 cases were reviewed; 800 were included for analysis, minimum follow-up of 35 months, median follow-up 15.1months. Median age 62.5; median PSA at presentation 7.0. Overall, 17.1% (n = 134) required salvage radiotherapy. On surgical histopathology, positive margins were associated with a relative risk increase of 2.45 (95% CI 1.81, 3.33; p<0.01) and lymphovascular invasion with a relative risk increase of 3.50 (95% CI 2.62, 4.67; p<0.01). CONCLUSIONS: This comprehensive dataset represents part of one of the largest series for radical prostatectomy in the UK. Analysis of these data have allowed us to precisely advise our patients on the likelihood that they will need salvage radiotherapy after radical prostatectomy, enabling optimally informed conversations both before and after surgery. Also to set expectations and optimism for cure. As functions of disease, not surgery, it is reasonable to expect these results to be generalisable. Source of Funding: N/A © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e892-e892 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information John Withington More articles by this author Alice Russell More articles by this author Tom Cahill More articles by this author Bradley Russell More articles by this author Julia Murray More articles by this author Chris Parker More articles by this author Simon Hughes More articles by this author Steve Hazell More articles by this author Netty Kinsella More articles by this author Declan Cahill More articles by this author Expand All Advertisement Loading ...