MP50-09 ROLE OF REPEAT BIOPSY IN THE FOLLOW-UP OF RENAL LESIONS WITH A PRIOR NON-DIAGNOSTIC BIOPSY OF THE SAME MASS

Abstract

total and fatal pathology-confirmed RCC by BMI immediately prior to diagnosis. Models were adjusted for diabetes, hypertension, smoking, alcohol intake, NSAID use, physical activity, and parity in women. Results from the two cohorts were pooled using random effects metaanalysis. RESULTS: We confirmed 351 cases of RCC, including 105 fatal cases, in NHS, and 225 cases in HPFS, with 49 fatal cases. Compared to women with normal BMI (18.5-24.9 kg/m2) immediately prior to diagnosis, obese women (BMI 30) had a non-significantly increased risk of RCC (HR 1.29, 95% CI: 0.97-1.72, p-trend1⁄40.04), adjusting for possible confounders. The HR for fatal RCC was similar (HR 1.30, 95% CI: 0.77-2.20, p-trend1⁄40.50). Obese men had a nonsignificantly increased risk of RCC (HR 1.44, 95% CI: 0.95-2.19, ptrend1⁄40.08), with a significantly increased risk of fatal RCC (HR 2.48, 95% CI: 1.08-5.72, p-trend1⁄40.16). There was no evidence of significant differences in the associations by sex. The pooled HRs for total RCC incidence were 1.21 (95% CI: 0.99-1.47) for overweight and 1.34 (95% CI: 1.05-1.69) for obese compared to normal weight, p-trend1⁄40.007. For fatal RCC, the pooled HRs were 1.11 (95% CI: 0.75-1.63) for overweight and 1.65 (0.95% CI: 0.90-3.04) for obese, p-trend1⁄40.18. CONCLUSIONS: Our results support that obesity is a risk factor for RCC incidence. Associations for fatal RCC were similar in magnitude to those for total RCC, though not statistically significant, suggesting that obesity is also adversely associated with risk of fatal RCC.