MP50-05 ORDER OF THROMBECTOMY FOR MANAGEMENT OF RENAL CELL CARCINOMA WITH INFERIOR VENA CAVA THROMBUS

Abstract

You have accessJournal of UrologyCME1 May 2022MP50-05 ORDER OF THROMBECTOMY FOR MANAGEMENT OF RENAL CELL CARCINOMA WITH INFERIOR VENA CAVA THROMBUS Yudai Ishiyama, Tsunenori Kondo, Kazuhiko Yoshida, Junpei Iizuka, Kazunari Tanabe, and Toshio Takagi Yudai IshiyamaYudai Ishiyama More articles by this author , Tsunenori KondoTsunenori Kondo More articles by this author , Kazuhiko YoshidaKazuhiko Yoshida More articles by this author , Junpei IizukaJunpei Iizuka More articles by this author , Kazunari TanabeKazunari Tanabe More articles by this author , and Toshio TakagiToshio Takagi More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002625.05AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Currently there is no consensus on whether to perform thrombectomy before kidney mobilization (“thrombus first”) or vice versa (“thrombus last”) for patients with renal cell carcinoma and inferior vena cava thrombus. The aim is to compare the perioperative outcomes between these two approaches. METHODS: We retrospectively evaluated 130 patients who underwent nephrectomy and thrombectomy at two institutions between 1992 and 2020. The cohort was classified into the thrombus-first and thrombus-last groups according to the order of the techniques used. Outcomes including the operative time, blood loss, and complications, especially the occurrence of intraoperative and postoperative pulmonary embolism, were compared. RESULTS: The thrombus-first and thrombus-last groups comprised 48 and 82 patients, respectively. Characteristics such as age, performance status, Charlson Comorbidity Index, renal function, and level of tumour thrombus were comparable between the two groups. Approximately 41% of the patients had distant metastasis. There were four cases (3.1%) of intraoperative pulmonary embolism, all from the thrombus-last group. Seven patients overall (5.4%) experienced pulmonary embolism postoperatively with six in the thrombus-last group (7.3%) and one in the thrombus-first (2.1%) group (p=0.259). The surgical time (291.0 min vs. 369.0 min, p<0.001) and the blood loss (1323.0 mL vs. 2100.0 mL, p<0.001) were significantly smaller for the thrombus-first group than for the thrombus-last group. Occurrence of complications was 25.0% and 43.9% in thrombus-first and thrombus-last groups, respectively (p=0.029), and 8.3% and 23.2% for events graded ≥3 (p=0.035). CONCLUSIONS: In surgery for renal cell carcinoma with inferior vena cava thrombus, performing thrombectomy before nephrectomy may serve to lessen complications, blood loss, and surgical time compared to nephrectomy before thrombectomy. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e865 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yudai Ishiyama More articles by this author Tsunenori Kondo More articles by this author Kazuhiko Yoshida More articles by this author Junpei Iizuka More articles by this author Kazunari Tanabe More articles by this author Toshio Takagi More articles by this author Expand All Advertisement PDF DownloadLoading ...