Abstract
RESULTS: 19 out of 20 specimens showed uptake of the ICGpHLIP construct. Cancerous lesions in the bladder were targeted with a sensitivity and specificity of 86.2% and 94.7%, respectively. Ratio values allowed us to distinguish between high grade invasive (R 1⁄4 3.15 +/0.57) and high grade non-invasive (R 1⁄4 1.90 +/0.341) carcinomas (p < 0.0005), as well as between high grade non-invasive carcinoma and CIS combined with dysplasia (R 1⁄4 1.340 +/0.45) (p < 0.05). Normal bladder mucosa showed no uptake of the ICG-pHLIP construct. CONCLUSIONS: The ICG-pHLIP consteuct targets the acidic microenvironment of human urothelial carcinoma. Ratio values demonstrated preferential uptake in high grade cancers but also demonstrated uptake in dysplastic tissue. Normal bladder tissue was spared. Our findings open the opportunity to develop novel approaches for diagnosis and treatment of bladder cancers.
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