MP5-11 PRIMARY GENITO-URINARY MELANOMA AMONG MEN AND WOMEN

Abstract

You have accessJournal of UrologyGeneral & Epidemiological Trends & Socioeconomics: Evidence-based Medicine & Outcomes I1 Apr 2015MP5-11 PRIMARY GENITO-URINARY MELANOMA AMONG MEN AND WOMEN Alejandro Sanchez, Dayron Rodriguez, Christopher B. Allard, Seth K. Bechis, Mark A. Preston, Jed-Sian Cheng, Glen W. Barrisford, and Adam S. Feldman Alejandro SanchezAlejandro Sanchez More articles by this author , Dayron RodriguezDayron Rodriguez More articles by this author , Christopher B. AllardChristopher B. Allard More articles by this author , Seth K. BechisSeth K. Bechis More articles by this author , Mark A. PrestonMark A. Preston More articles by this author , Jed-Sian ChengJed-Sian Cheng More articles by this author , Glen W. BarrisfordGlen W. Barrisford More articles by this author , and Adam S. FeldmanAdam S. Feldman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.238AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Primary genito-urinary (GU) melanoma is rare. Therefore, in order to better elucidate the characteristics of this disease we utilized a large population-based cancer registry to examine the epidemiology, natural history, pathological characteristics, prognostic factors, and survival outcomes. Furthermore, we sought to evaluate if these outcomes differed among men and women. METHODS The Surveillance, Epidemiology, and End Results (SEER) database (1973–2010) was used to identify cases by tumor site and histology codes. The associations between demographic, clinical, pathological characteristics, and disease specific survival (DSS) were examined. RESULTS A total of 1586 histologically confirmed cases were identified. The cohort was composed of 123 males (77 penile, 35 scrotal, and 11 urinary tract) and 1463 women (1059 vulvar, 348 vaginal, and 56 urinary tract) with mean ages of 63 years and 66 years, respectively. The overall annual age-adjusted incidence rate was 0.011 cases per 100,000. Overall, 60% of had localized disease on diagnosis. The most common location in men was penile (63%) and in women was vulvar (72%). The majority of patients (89%) received cancer directed surgery. Overall, women had worse median DSS compared to men (p = < 0.01). On univariate analysis, age, sex, race, marital status, stage, anatomic location, Breslow thickness, presence of ulcerations, and lymph node involvement were all significant predictors of survival (p = < 0.01). On multivariate analysis, a worse outcome was associated with increasing age, distant stage, positive lymph node involvement, and location (vulvar in women and penile in men). CONCLUSIONS This series represents the largest cohort of primary GU melanoma studied to date. Primary GU melanoma commonly presents with localized disease. Women have a worse median DSS compared to men. Adverse prognostic factors include increasing age, distant stage, positive lymph node involvement, and location (vulvar in women and penile in men). © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e49 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Alejandro Sanchez More articles by this author Dayron Rodriguez More articles by this author Christopher B. Allard More articles by this author Seth K. Bechis More articles by this author Mark A. Preston More articles by this author Jed-Sian Cheng More articles by this author Glen W. Barrisford More articles by this author Adam S. Feldman More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...