MP48-08 ONCOLOGIC OUTCOMES OF SIMPLE ENUCLEATION PARTIAL NEPHRECTOMY IN SPORADIC TYPE 2 PAPILLARY RENAL CELL CARCINOMA

Abstract

You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy V1 Apr 2018MP48-08 ONCOLOGIC OUTCOMES OF SIMPLE ENUCLEATION PARTIAL NEPHRECTOMY IN SPORADIC TYPE 2 PAPILLARY RENAL CELL CARCINOMA Avinash Maganty, Andres Correa, Jathin Bandari, Ronald Hrebinko, Benjamin Davies, Jodi Maranchie, and Stephen Jackman Avinash MagantyAvinash Maganty More articles by this author , Andres CorreaAndres Correa More articles by this author , Jathin BandariJathin Bandari More articles by this author , Ronald HrebinkoRonald Hrebinko More articles by this author , Benjamin DaviesBenjamin Davies More articles by this author , Jodi MaranchieJodi Maranchie More articles by this author , and Stephen JackmanStephen Jackman More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1507AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Papillary type 2 renal cell carcinoma (RCC) has been associated with poor prognosis and increased risk of local recurrence following studies in patients with Hereditary Leiomyomatosis and RCC. The current recommendation for patients found to have papillary type 2 features on biopsy is for radical nephrectomy or partial nephrectomy with a wide margin. Here we assess the margin rate along with fossa recurrence rate of patients with sporadic type 2 papillary RCC that underwent simple enucleation partial nephrectomy as compared to those with clear cell RCC. METHODS We performed a retrospective chart review of all patients with a small renal mass (4cm or less) who underwent simple enucleation partial nephrectomy and were found to have papillary type 2 RCC or clear cell RCC over a 10-year period (2006-2016). Information regarding patient demographics, surgical technique, histological subtype, grade, margin status, recurrence rate, and development of metastatic disease was collected from the medical record. All patients with known histology prior to partial nephrectomy were excluded from the study, as were patients with mixed histology or patients who underwent laparoscopic/robotic procedures. RESULTS 113 patients met criteria for the study. 27 (24.0%) patients were found to have papillary type 2 RCC. There were more males with papillary type 2 RCC (85.2%) than clear cell (60.5%, p = 0.008). The margin rate for both groups was comparable with 11% of patients having a positive margin in the papillary type 2 group compared to 9.3% in the clear cell RCC group (p=0.78). Local recurrence was comparable with only 2 (7.4%) patients developing a fossa recurrence in the papillary type 2 group compared to 5 (5.8%) in the clear cell RCC group (p=0.76). Papillary type 2 compared to clear cell was associated with higher grade (100% vs. 22%, respectively, p < 0.001) and metastatic disease (14.8% vs. 2.3%, respectively, p=0.012) at a median 2 year follow-up. CONCLUSIONS The margin and fossa recurrence rate seen following simple enucleation partial nephrectomy was comparable between sporadic papillary type 2 and clear cell histology. Therefore simple enucleation can be performed with acceptable surgical outcomes in sporadic papillary type 2 RCC. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e627-e628 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Avinash Maganty More articles by this author Andres Correa More articles by this author Jathin Bandari More articles by this author Ronald Hrebinko More articles by this author Benjamin Davies More articles by this author Jodi Maranchie More articles by this author Stephen Jackman More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...