MP48-06 HYPOGONADAL MEN TAKING CLOMIPHENE CITRATE REPORT SIMILAR SATISFACTION COMPARED TO MEN ON TESTOSTREONE REPLACEMENT THERAPY

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Medical and Non-surgical1 Apr 2014MP48-06 HYPOGONADAL MEN TAKING CLOMIPHENE CITRATE REPORT SIMILAR SATISFACTION COMPARED TO MEN ON TESTOSTREONE REPLACEMENT THERAPY Ranjith Ramasamy, Jason Scovell, Jason Kovac, James Dupree, Gavin Langille, Dolores Lamb, and Larry Lipshultz Ranjith RamasamyRanjith Ramasamy More articles by this author , Jason ScovellJason Scovell More articles by this author , Jason KovacJason Kovac More articles by this author , James DupreeJames Dupree More articles by this author , Gavin LangilleGavin Langille More articles by this author , Dolores LambDolores Lamb More articles by this author , and Larry LipshultzLarry Lipshultz More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1480AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail Introduction and Objectives The efficacy of oral clomiphene citrate (CC) in the treatment of male hypogonadism has been reported. We compared satisfaction and treatment efficacy in men with symptomatic hypogonadism taking CC, testosterone gel (T gel), and testosterone injections (T injections). Methods Men receiving CC or T gel or T injections for symptomatic hypogonadism (total testosterone < 300 ng/dl) were asked to report satisfaction with their current treatment regimen with ADAM and qADAM scores. Serum testosterone levels were collected on the same day that men filled out the ADAM questionnaire. Treatment efficacy was evaluated using pre- and post-treatment serum testosterone, and satisfaction was assessed using androgen deficiency in aging male (ADAM) and quantitative ADAM (qADAM) questionnaire scores. Results The charts of 451 men on testosterone supplementation (51 on CC, 265 on T injections, and 135 on T gel) were reviewed. The mean serum total T levels in men on CC (525 ng/dL) was lower (p<0.01) than men taking T injections (1015 ng/dL), but similar to serum total T in men on gels (453.3 ng/dL, p=0.07). Post-treatment testosterone levels were higher in men taking CC, T injections and T gels compared to pre-treatment levels (227 ng/dL, 221 ng/dL, 211 ng/dL p<0.01) Despite differences in serum T, men on CC, T injection, and T gel reported similar satisfaction levels. Both the ADAM scores (2.37, 2.81, and 3.17) and quantitative ADAM scores (37.2, 36.8, and 35.6) for the men on different testosterone supplementation regimens were similar. Men taking CC were younger (38.5y) than men taking T injections (46.8y) or T gels (59.4, p< 0.01). Conclusions Testosterone supplementation regimens including CC, T gels and T injections are efficacious in improving serum total testosterone levels. However, men taking clomiphene citrate or testosterone gels report similar satisfaction levels compared to men taking testosterone injections despite lower serum total testosterone levels. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e529 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Ranjith Ramasamy More articles by this author Jason Scovell More articles by this author Jason Kovac More articles by this author James Dupree More articles by this author Gavin Langille More articles by this author Dolores Lamb More articles by this author Larry Lipshultz More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...