MP47-06 CHARACTERISTICS OF SECONDARY, PRIMARY, AND COMPENSATED HYPOGONADISM IN CAUCASIAN-EUROPEAN MEN PRESENTING FOR NEW ONSET ERECTILE DYSFUNCTION - RESULTS OF A CROSS-SECTIONAL SURVEY

Abstract

You have accessJournal of UrologySexual Function/Dysfunction: Evaluation1 Apr 2016MP47-06 CHARACTERISTICS OF SECONDARY, PRIMARY, AND COMPENSATED HYPOGONADISM IN CAUCASIAN-EUROPEAN MEN PRESENTING FOR NEW ONSET ERECTILE DYSFUNCTION - RESULTS OF A CROSS-SECTIONAL SURVEY Eugenio Ventimiglia, Paolo Capogrosso, Luca Boeri, Andrea Russo, Silvia Ippolito, Donatella Moretti, Roberta Scano, Rayan Matloob, Lina Bua, Luca Villa, Franco Gaboardi, Francesco Montorsi, and Andrea Salonia Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Paolo CapogrossoPaolo Capogrosso More articles by this author , Luca BoeriLuca Boeri More articles by this author , Andrea RussoAndrea Russo More articles by this author , Silvia IppolitoSilvia Ippolito More articles by this author , Donatella MorettiDonatella Moretti More articles by this author , Roberta ScanoRoberta Scano More articles by this author , Rayan MatloobRayan Matloob More articles by this author , Lina BuaLina Bua More articles by this author , Luca VillaLuca Villa More articles by this author , Franco GaboardiFranco Gaboardi More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea SaloniaAndrea Salonia More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.325AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES An association between erectile dysfunction (ED) and testosterone deficiency (TD) has been variously described in the literature, with mixed results in terms of effectiveness of the combination therapy for both conditions. We sought whether different forms of hypogonadism can be distinguished among Caucasian-European men presenting for new-onset ED. METHODS Complete demographic, clinical and laboratory data from the last 303 consecutive patients seeking medical help for ED at the same academic outpatient clinic were analyzed. Four groups of individuals were defined according to Tajar et al. (J Clin Endocrinol Metab. 2010;95:1810-8): eugonadal [normal testosterone (T ≥ 3.03 ng/mL) and normal LH (≤9.4 mUI/mL)], secondary (low T and low/normal LH), primary (low T and elevated LH), and compensated (normal T and elevated LH) hypogonadism. Health-significant comorbidities were scored with the Charlson Comorbidity Index (CCI; categorized 0 vs 1 vs ≥2). Testicular volume was assessed with a Prader orchidometer. Patients were invited to complete both the IPSS and the IIEF questionnaires. Descriptive statistics tested differences among the aforementioned groups. RESULTS Of all, eugonadism, secondary, primary, and compensated hypogonadism were found in 233 (76.4%), 45 (14.8%), 8 (2.6%), and 19 (6.2%) men, respectively. Despite being younger, primary hypogonadal men were the least healthy (CCI defined) group, having higher BMI, waist circumference, IPSS score, and lower IIEF sexual desire score (all p<0.03). Overall, health status, waist circumference, BMI, and CCI worsened according to the defined gonadal status, with a less favorable profile in primary and secondary hypogonadal men as compared to compensated ones (all p<0.01). Among IIEF domains, sexual desire was the only one negatively influenced by the gonadal status (p=0.03); conversely, erectile function domain did not vary significantly among the analyzed groups. Interestingly, LUTS severity (as for IPSS scores) worsened according to the gonadal status (p=0.01). CONCLUSIONS Overall, the prevalence of TD was 23.6% within our cohort of Caucasian-European men presenting for new-onset ED. Clinical, endocrine and metabolic characteristics significantly worsen according to the defined gonadal status. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e628-e629 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Eugenio Ventimiglia More articles by this author Paolo Capogrosso More articles by this author Luca Boeri More articles by this author Andrea Russo More articles by this author Silvia Ippolito More articles by this author Donatella Moretti More articles by this author Roberta Scano More articles by this author Rayan Matloob More articles by this author Lina Bua More articles by this author Luca Villa More articles by this author Franco Gaboardi More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...