MP46-18 PATIENTS REPORT SATISFACTION/REGRET FOLLOWING FOCAL THERAPY FOR LOCALIZED PROSTATE CANCER: A PROSPECTIVE MULTICENTER EVALUATION

Abstract

You have accessJournal of UrologyProstate Cancer: Localized: Ablative Therapy (MP46)1 Sep 2021MP46-18 PATIENTS REPORT SATISFACTION/REGRET FOLLOWING FOCAL THERAPY FOR LOCALIZED PROSTATE CANCER: A PROSPECTIVE MULTICENTER EVALUATION Alireza Ghoreifi, Masatomo Kaneko, Samuel Peretsman, Atsuko Iwata, Aliasger Shakir, Dordaneh Sugano, Jie Cai, Giovanni Cacciamani, Daniel Park, Osamu Ukimura, Duke Bahn, Inderbir Gill, and Andre Luis Abreu Alireza GhoreifiAlireza Ghoreifi More articles by this author , Masatomo KanekoMasatomo Kaneko More articles by this author , Samuel PeretsmanSamuel Peretsman More articles by this author , Atsuko IwataAtsuko Iwata More articles by this author , Aliasger ShakirAliasger Shakir More articles by this author , Dordaneh SuganoDordaneh Sugano More articles by this author , Jie CaiJie Cai More articles by this author , Giovanni CacciamaniGiovanni Cacciamani More articles by this author , Daniel ParkDaniel Park More articles by this author , Osamu UkimuraOsamu Ukimura More articles by this author , Duke BahnDuke Bahn More articles by this author , Inderbir GillInderbir Gill More articles by this author , and Andre Luis AbreuAndre Luis Abreu More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002067.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The objective is to evaluate the treatment decision satisfaction and regret among patients who underwent Focal Therapy (FT) for localized prostate cancer (PCa) with high-intensity focused ultrasound (HIFU) or cryoablation (CRYO). METHODS: We identified consecutive patients who underwent hemi-gland HIFU or CRYO FT as primary treatment for localized PCa at three US institutions (IRB# HS-17-00749). A survey with validated questionnaires was mailed between February and December of 2020, including: 5-question Decision Regret Scale (DRS); International Prostate Symptom Score (IPSS); and International Index of Erectile Function (IIEF-5). Potency was defined as IIEF-5 ≥ 18. The regret score was calculated based on the 5 items of DRS (Figure). Agreement with each item is measured on a 5-point scale and the final score is converted to a 0-100 scale. Regret was defined as DRS ≥ 26. Multivariable logistic regression models were applied to assess baseline and post-FT predictors for treatment decision regret. Statistically significant if p<0.05. RESULTS: Out of 236 patients, 143 (61%) responded the survey (71/116 HIFU and 72/120 CRYO). Baseline characteristics were similar between responders and no-responders. For the responders, the median (IQR) follow-up was 43 (26-68) months. The treatment decision regret rate was 19.6%, being CRYO 23.6% vs. HIFU 15.5% (OR 1.7, p=0.22). The Figure shows the details of patients’ responses to each DRS question. Higher PSA at nadir (OR 1.48, 95%CI 1.1-2, p=0.009) post FT, presence of PCa on the follow-up biopsy (OR 3.98, 95%CI 1.5-10.6, p=0.006), higher IPSS after FT (OR 1.18, 95%CI 1.01-1.04, p=0.03), and de-novo impotence (OR 6.67, 95%CI 1.57-27, p=0.03) were independent predictors of treatment decision regret. CONCLUSIONS: Focal therapy for localized PCa is well-accepted by the patients. Higher PSA at nadir, presence of cancer on the follow-up biopsy, higher post-operative IPSS, and de-novo impotence are independent predictors of treatment decision regret. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e820-e821 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Alireza Ghoreifi More articles by this author Masatomo Kaneko More articles by this author Samuel Peretsman More articles by this author Atsuko Iwata More articles by this author Aliasger Shakir More articles by this author Dordaneh Sugano More articles by this author Jie Cai More articles by this author Giovanni Cacciamani More articles by this author Daniel Park More articles by this author Osamu Ukimura More articles by this author Duke Bahn More articles by this author Inderbir Gill More articles by this author Andre Luis Abreu More articles by this author Expand All Advertisement Loading ...