MP46-15 SURVIVAL OF PATIENTS WITH SQUAMOUS DIFFERENTIATED UROTHELIAL CARCINOMA COMPARED TO PURE UROTHELIAL CARCINOMA FOLLOWING RADICAL CYSTECTOMY IN A RURAL HEALTHCARE SYSTEM

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP46-15 SURVIVAL OF PATIENTS WITH SQUAMOUS DIFFERENTIATED UROTHELIAL CARCINOMA COMPARED TO PURE UROTHELIAL CARCINOMA FOLLOWING RADICAL CYSTECTOMY IN A RURAL HEALTHCARE SYSTEM Alexander Battin, Mystie Chen, Jasmine Kashkoush, Wanyan Ma, Donovan Harris, Karl Schranz, Zhan Wu, and Matthew Meissner Alexander BattinAlexander Battin More articles by this author , Mystie ChenMystie Chen More articles by this author , Jasmine KashkoushJasmine Kashkoush More articles by this author , Wanyan MaWanyan Ma More articles by this author , Donovan HarrisDonovan Harris More articles by this author , Karl SchranzKarl Schranz More articles by this author , Zhan WuZhan Wu More articles by this author , and Matthew MeissnerMatthew Meissner More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003292.15AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Approximately 80% of urothelial carcinoma (UC) is pure while the other 20% is comprised of variant histology. The most common histological variant is squamous differentiation urothelial carcinoma (SqUC). Small series suggest an overall poor prognosis for SqUC compared to pure UC (pUC). The aim of this study is to compare survival outcomes between patients with SqUC and pUC following radical cystectomy in a large, rural healthcare system. METHODS: A total of 335 patients were scheduled for cystectomy at a rural tertiary care center between 2008 to 2019. Patients were followed post-operatively and evaluated for recurrence. Recurrence free survival (RFS) was defined as time after cystectomy without clinical evidence of disease until last follow up or date of death. Patients that underwent planned cystectomy that were unable to be performed due to extent of disease or mixed variant/differentiation histology will be excluded from analysis. Pathology from TURBT and cystectomy will be reviewed for inclusion. Statistical significance will be determined using XLSTAT software with log-rank test using a p-value less than 0.05. RESULTS: Of the 333 patients that underwent planned cystectomy, 225 (67.6%) were pUC, 47 (14.1%) were SqUC, 42 (12.6%) were mixed variant/differentiated UC, and 19 (5.7%) were non-UC malignancies. Furthermore, 32 (9.6%) radical cystectomies were aborted due to extent of disease. Average age at time of cystectomy for SqUC and pUC were 68.4 and 68.7 years, respectively. Overall survival in SqUC was significantly lower with median of 28 months compared to 56 months for pUC (p=0.011). This is demonstrated as a Kaplan-Meier survival curve in Figure 1. The SqUC group also had significantly lower RFS with median of 15 months compared to 50 months for pUC group (p=0.032) (Figure 2). CONCLUSIONS: Urothelial carcinoma with squamous differentiation has significantly lower overall survival and recurrent free survival compared to pUC after radical cystectomy in the rural healthcare setting. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e638 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Alexander Battin More articles by this author Mystie Chen More articles by this author Jasmine Kashkoush More articles by this author Wanyan Ma More articles by this author Donovan Harris More articles by this author Karl Schranz More articles by this author Zhan Wu More articles by this author Matthew Meissner More articles by this author Expand All Advertisement PDF downloadLoading ...