MP45-05 PRESENCE OF INTRADUCTAL CARCINOMA IN NEEDLE BIOPSY IS A SIGNIFICANT PROGNOSTIC PARAMETER FOR PROSTATE CANCER IN RADICAL PROSTATECTOMY PATIENTS

Abstract

You have accessJournal of UrologyProstate Cancer: Localized III1 Apr 2014MP45-05 PRESENCE OF INTRADUCTAL CARCINOMA IN NEEDLE BIOPSY IS A SIGNIFICANT PROGNOSTIC PARAMETER FOR PROSTATE CANCER IN RADICAL PROSTATECTOMY PATIENTS Masashi Kato, Toyonori Tsuzuki, Kyosuke Kimura, Yasuhito Funahashi, Naoto Sassa, Takashi Fujita, Yoshihisa Matsukawa, Yasushi Yoshino, Tokunori Ymamamoto, and Momokazu Gotoh Masashi KatoMasashi Kato More articles by this author , Toyonori TsuzukiToyonori Tsuzuki More articles by this author , Kyosuke KimuraKyosuke Kimura More articles by this author , Yasuhito FunahashiYasuhito Funahashi More articles by this author , Naoto SassaNaoto Sassa More articles by this author , Takashi FujitaTakashi Fujita More articles by this author , Yoshihisa MatsukawaYoshihisa Matsukawa More articles by this author , Yasushi YoshinoYasushi Yoshino More articles by this author , Tokunori YmamamotoTokunori Ymamamoto More articles by this author , and Momokazu GotohMomokazu Gotoh More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1202AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail Introduction and Objectives Presence of intraductal carcinoma of the prostate (IDC-P) is an adverse prognostic factor of PSA failure for radical prostatectomy patients. Recently, we demonstrated IDC-P in radical prostatectomy predict progression-free survival (PFS) and cancer-specific survival (CSS). We aimed to evaluate whether IDC-P in needle biopsies is also an adverse prognostic parameter for PFS and CSS in radical prostatectomy patients. Methods We retrospectively evaluated 206 high-risk prostate cancer patients treated with radical prostatectomy between 1991 and 2005 in the hospitals that the authors were affiliated to and reviewed slides of prostatectomy specimens. Data on serum PSA level, biopsy Gleason score (bGS, >8 or not), cT stage (pT2 or more), presence of Gleason pattern 5 were analyzed. Patient characteristics were analyzed using Fisher's exact test. Multivariate Cox proportional hazard regression models were developed to predict PFS and CSS. Results The median age of the patients was 69 years. The median follow-up period was 83 months. IDC-P component was detected in 102 patients. Forty-four patients showed clinical failure, and 20 patients died of the disease. Patients with IDCP showed a higher increased PSA level, higher increased bGS, and more advanced cT than those without IDC-P (p < 0.0001). In univariate analysis, IDC-P (p < 0.0001), cT (p < 0.0001), bGS (p = 0.0002), and presence of Gleason pattern 5 (p=0.004) were significantly associated with PFS; IDC-P (p < 0.001) and cT (p = 0.02) were significantly associated with CSS. In multivariate analysis, IDC-P (p< 0.0001; hazard ratio (HR), 3.574) and cT (p= 0.004; HR, 3.087) were significantly associated with PFS; IDC-P (p = 0.001; HR, 8.405) and PSA level (p = 0.0044; HR, 2.920) were significantly associated with CSS. Conclusions The presence of IDC-P in needle biopsy is a prognostic parameter for both PFS and CSS in radical prostatectomy patients. The presence of IDC-P in needle biopsy also can be a useful parameter to predict patientsf clinical outcome prior to radical prostatectomy. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e460-e461 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Masashi Kato More articles by this author Toyonori Tsuzuki More articles by this author Kyosuke Kimura More articles by this author Yasuhito Funahashi More articles by this author Naoto Sassa More articles by this author Takashi Fujita More articles by this author Yoshihisa Matsukawa More articles by this author Yasushi Yoshino More articles by this author Tokunori Ymamamoto More articles by this author Momokazu Gotoh More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...