MP45-18 IDENTIFICATION OF DNA DAMAGE REPAIR-ASSOCIATED PROGNOSTIC BIOMARKERS FOR PROSTATE CANCER USING TRANSCRIPTOMIC DATA ANALYSIS

Abstract

You have accessJournal of UrologyCME1 May 2022MP45-18 IDENTIFICATION OF DNA DAMAGE REPAIR-ASSOCIATED PROGNOSTIC BIOMARKERS FOR PROSTATE CANCER USING TRANSCRIPTOMIC DATA ANALYSIS Shu-Pin Huang, Pai-Chi Teng, Chia-Hsin Liu, Ting-Yi Lin, Yi-Chun Cho, Yo-Liang Lai, Shu-Chi Wang, Hsin-Chih Yeh, Chih-Pin Chuu, Deng-Neng Chen, Wei-Chung Cheng, and Chia-Yang Li Shu-Pin HuangShu-Pin Huang More articles by this author , Pai-Chi TengPai-Chi Teng More articles by this author , Chia-Hsin LiuChia-Hsin Liu More articles by this author , Ting-Yi LinTing-Yi Lin More articles by this author , Yi-Chun ChoYi-Chun Cho More articles by this author , Yo-Liang LaiYo-Liang Lai More articles by this author , Shu-Chi WangShu-Chi Wang More articles by this author , Hsin-Chih YehHsin-Chih Yeh More articles by this author , Chih-Pin ChuuChih-Pin Chuu More articles by this author , Deng-Neng ChenDeng-Neng Chen More articles by this author , Wei-Chung ChengWei-Chung Cheng More articles by this author , and Chia-Yang LiChia-Yang Li More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002611.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: In the recent decade, the importance of DNA damage repair (DDR) and its clinical appli- cation have been firmly recognized in prostate cancer (PC). For example, olaparib was just approved in May 2020 to treat metastatic castration-resistant PC with homologous recombination repair-mu- tated genes; however, not all patients can benefit from olaparib, and the treatment response de- pends on patient-specific mutations. This highlights the need to understand the detailed DDR biol- ogy further and develop DDR-based biomarkers. METHODS: In this study, we establish a four-gene panel of which the expression is significantly associated with overall survival (OS) and progression-free survival (PFS) in PC patients from the TCGA-PRAD database. RESULTS: The established panel includes DNTT, EXO1, NEIL3, and EME2 genes. Patients with higher expression of the four identified genes have signifi- cantly worse OS and PFS. This significance also exists in a multivariate Cox regression model ad- justing for age, PSA, TNM stages, and Gleason scores. Moreover, the expression of the four-gene panel is highly correlated with aggressiveness based on well-known PAM50 and PCS subtyping classifiers. CONCLUSIONS: Using publicly available databases, we successfully validate the four-gene panel as hav- ing the potential to serve as a prognostic and predictive biomarker for PC specifically based on DDR biology. Source of Funding: This study was supported by grants from the Ministry of Science and Technology, Taiwan, R.O.C. (grant No. MOST 108-2314-B-037-079-MY3, MOST 109-2622-E-039-004-CC2, MOST 109-2628- E-039-001-MY3, MOST 109-2327-B-039-002, MOST109-2314-B-037-106-MY3 and MOST 109-2320-B- 037-007-MY3), Kaohsiung Medical University Chung-Ho Memorial Hospital (grant No. KMUH105- 5M55), China Medical University Hospital (grant No. DMR-109-223, DMR-110-072 and DMR-110- 244), and China Medical University, Taiwan, R.O.C. (grant No. CMU107-S-24, CMU108-Z-02, CMU108-S-22, CMU109-MF-61 and CMU110-MF-64) © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e770 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shu-Pin Huang More articles by this author Pai-Chi Teng More articles by this author Chia-Hsin Liu More articles by this author Ting-Yi Lin More articles by this author Yi-Chun Cho More articles by this author Yo-Liang Lai More articles by this author Shu-Chi Wang More articles by this author Hsin-Chih Yeh More articles by this author Chih-Pin Chuu More articles by this author Deng-Neng Chen More articles by this author Wei-Chung Cheng More articles by this author Chia-Yang Li More articles by this author Expand All Advertisement PDF DownloadLoading ...