MP45-11 FEMALE SEXUAL DYSFUNCTION AND TYPE 2 DIABETES: RESULTS FROM THE DIABETES PREVENTION PROGRAM OUTCOMES STUDY (DPPOS)

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP45-11 FEMALE SEXUAL DYSFUNCTION AND TYPE 2 DIABETES: RESULTS FROM THE DIABETES PREVENTION PROGRAM OUTCOMES STUDY (DPPOS) Priyanka Gupta, Lindsay Doherty, Marinella Temprosa, Hunter Wessells, Rodica Pop-Busui, Kishore Gadde, Arthur H. Owora, Aruna V. Sarma, and DPP Research Group Priyanka GuptaPriyanka Gupta More articles by this author , Lindsay DohertyLindsay Doherty More articles by this author , Marinella TemprosaMarinella Temprosa More articles by this author , Hunter WessellsHunter Wessells More articles by this author , Rodica Pop-BusuiRodica Pop-Busui More articles by this author , Kishore GaddeKishore Gadde More articles by this author , Arthur H. OworaArthur H. Owora More articles by this author , Aruna V. SarmaAruna V. Sarma More articles by this author , and DPP Research Group More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003291.11AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Female sexual dysfunction (FSD) has been reported to be more common in women with T2D. However, detailed risk profiles are lacking. We sought to determine the burden and correlates of FSD in a well characterized cohort of women with Prediabetes (PreD) and T2D enrolled in the DPPOS. METHODS: Between 1996-1999, 3,234 adults with PreD were randomized to intensive lifestyle intervention, masked metformin, or placebo in the DPP. In 2001, open-label metformin was continued for those originally randomized to it and modified lifestyle intervention offered to all. In 2016-2017, 1320 of 1464 participants completed the Female Sexual Function Index (FSFI). 426 women were sexually active and included in the current report. FSD was defined as FSFI≥26.55. A backwards selection multivariable logistic regression model estimated odds of FSD for sociodemographic, clinical, and diabetes-related covariates significant in bivariate analysis. RESULTS: Overall, 185 (43%) women met the criteria for FSD. After adjustment for treatment arm, age and race, depression (defined by the Beck Depression inventory or antidepressant use) and weekly urinary incontinence were both associated with over a two-fold (OR=2.81, 95%CI=1.57, 5.02; and OR=2.14, 95%CI=1.31, 3.51) increase in odds of FSD, respectively. Women who reported hysterectomy were 1.95 times more likely (95%CI=1.07, 3.54) to report FSD. Mean study BMI was slightly protective for FSD (OR=0.93, 95%CI=0.89, 0.96). Neither DPP treatment group nor any diabetes-related factors were associated with FSD. CONCLUSIONS: FSD is highly prevalent in this population of women with PreD and T2D. Our findings suggest that FSD in this cohort is most strongly associated with depression. The lack of association between any measures of diabetes or glycemic control suggests that the sexual response in women is more likely to be affected by psychosocial aspects than by metabolic control or complications of diabetes. Source of Funding: National Institute of Diabetes and Digestive and Kidney Diseases (UDK048489, UDK048339, UDK048377, UDK048349, UDK048381, UDK048468, UDK048434, UDK048485, UDK048375, UDK048514, UDK048437, UDK048413, UDK048411, UDK048406, UDK048380, UDK048397, UDK048412, UDK048404, UDK048387, UDK048407, UDK048443, and UDK048400) © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e625 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Priyanka Gupta More articles by this author Lindsay Doherty More articles by this author Marinella Temprosa More articles by this author Hunter Wessells More articles by this author Rodica Pop-Busui More articles by this author Kishore Gadde More articles by this author Arthur H. Owora More articles by this author Aruna V. Sarma More articles by this author DPP Research Group More articles by this author Expand All Advertisement PDF downloadLoading ...