MP44-19 EFFECTS OF PROSTATE-SPECIFIC ANTIGEN SCREENING ON PROSTATE CANCER INCIDENCE AND MORTALITY: A POPULATION-BASED COHORT STUDY IN CHINA

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP44-19 EFFECTS OF PROSTATE-SPECIFIC ANTIGEN SCREENING ON PROSTATE CANCER INCIDENCE AND MORTALITY: A POPULATION-BASED COHORT STUDY IN CHINA Yongle Zhan, Xiaohao Ruan, Da Huang, Jingyi Huang, Jinlun Huang, Tsun Tsun Chun, Brian Ho, Ada Ng, James Tsu, and Rong Na Yongle ZhanYongle Zhan More articles by this author , Xiaohao RuanXiaohao Ruan More articles by this author , Da HuangDa Huang More articles by this author , Jingyi HuangJingyi Huang More articles by this author , Jinlun HuangJinlun Huang More articles by this author , Tsun Tsun ChunTsun Tsun Chun More articles by this author , Brian HoBrian Ho More articles by this author , Ada NgAda Ng More articles by this author , James TsuJames Tsu More articles by this author , and Rong NaRong Na More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003290.19AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Evidence regarding the benefit of prostate-specific antigen (PSA) testing for prostate cancer (PCa) is limited in China. Scarce research so far explores the optimal frequency and interval of repeated PSA testing. This study aims to evaluate the effects of serial screening in different frequencies and intervals against PCa incidence and mortality among Chinese population. METHODS: Data of this study came from the Chinese Electronic Health Records Research in Yinzhou (CHERRY) Study. Briefly, the CHERRY study is a population-based cohort study comprising more than one million adults enrolled from 1 January 2009 in Yinzhou, China. The population census, primary care, electronic medical records, health checks, surveillance, and death registry databases have been integrated into the CHERRY study. A total of 420,941 male participants aged over 45 at recruitment were included in the present study. Among them, a subgroup of 75,362 men who have undergone any PSA testing was selected for analysis. The number of receiving PSA screening, screening frequency and interval, PCa diagnosis and death were extracted from the electronic health records system. RESULTS: People receiving more than three times of PSA testing had 67% (95% confidence interval [CI]: 48-88%) higher risks of PCa detection, but 64% (95%CI: 30-82%) lower risks of PCa-specific mortality and 28% (95%CI: 23-33%) lower risks of overall mortality. Receiving at least one screening per four years could increase 25% (95%CI: 13-36%) risks of PCa detection, but decrease 70% (95%CI: 43-84%) and 23% (95%CI: 18-27%) risks of PCa-specific and overall mortality. For those repeated attenders, 2-yr to 3-yr intervals could decrease 50-85% risks of PCa-specific mortality and 9-57% risks of overall mortality (Figure 1). CONCLUSIONS: This study provides the first evidence for the benefits of PSA screening in Chinese general population, and supports that receiving serial screening at least once per four-year is beneficial for overall and prostate cancer-specific survival. Source of Funding: This work was in supported by grants from National Natural Science Foundation of China (Grant No. 81972645), Shanghai Youth Talent Support Program, intramural funding of The University of Hong Kong to Dr. Rong Na, and Shanghai Sailing Program (22YF1440500) to Dr. Da Huang © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e619 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yongle Zhan More articles by this author Xiaohao Ruan More articles by this author Da Huang More articles by this author Jingyi Huang More articles by this author Jinlun Huang More articles by this author Tsun Tsun Chun More articles by this author Brian Ho More articles by this author Ada Ng More articles by this author James Tsu More articles by this author Rong Na More articles by this author Expand All Advertisement PDF downloadLoading ...