MP44-09 NON-ALCOHOLIC FATTY LIVER DISEASE IS ASSOCIATED WITH GREATER SEVERITY OF INTRA PROSTATIC INFLAMMATION IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA

Abstract

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Basic Research & Pathophysiology1 Apr 2016MP44-09 NON-ALCOHOLIC FATTY LIVER DISEASE IS ASSOCIATED WITH GREATER SEVERITY OF INTRA PROSTATIC INFLAMMATION IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA Giorgio Ivan Russo, Sebastiano Cimino, Giulio Reale, Daniele Urzì, Luca Vanella, Fabio Motta, Rosario Caltabiano, Lidia Puzzo, Valeria Sorrenti, and Giuseppe Morgia Giorgio Ivan RussoGiorgio Ivan Russo More articles by this author , Sebastiano CiminoSebastiano Cimino More articles by this author , Giulio RealeGiulio Reale More articles by this author , Daniele UrzìDaniele Urzì More articles by this author , Luca VanellaLuca Vanella More articles by this author , Fabio MottaFabio Motta More articles by this author , Rosario CaltabianoRosario Caltabiano More articles by this author , Lidia PuzzoLidia Puzzo More articles by this author , Valeria SorrentiValeria Sorrenti More articles by this author , and Giuseppe MorgiaGiuseppe Morgia More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.265AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES It has been previously demonstrated the association between metabolic syndrome (MetS), benign prostatic hyperplasia (BPH) and prostate inflammation. We have recently shown that insulin resistance (IR) and non-alcoholic fatty liver disease (NAFLD) were associated with greater severity of lower urinary tract symptoms (LUTS). In this study we aimed to investigate the association between IR, NAFLD and intraprostatic inflammation in patients undergoing transurethral resection of the prostate (TURP) for moderate-to-severe LUTS. METHODS Between January 2012 and June 2013, we enrolled 129 consecutive patients with IPSS =12, PSA <4 ng/ml or PSA =4 ng/ml but previous negative prostate biopsy, Qmax <15 mL/sec, prostate volume =30 ml and =80 ml. A condition of IR was defined in the presence of a value homeostasis model assessment (HOMA) greater than or equal to 3. The presence of NAFLD was defined in the presence of a value of Fatty Liver Index (FLI) greater than or equal to 40 (specificity 72 %, sensitivity 82%, AUC 81%). The protocol was approved by the local ethics committee (ID: 578). During TURP procedure we collected tissue samples for the evaluation of the degree of inflammatory infiltrate according to the classification used by Irani et al. The degree of inflammatory score (IS) was obtained by combining three different histological parameters (grade and aggressiveness), with a score ranging between 0 and 6. RESULTS The median HOMA -Index was 1.69 (IQR: 0.89-3.43), the median FLI was 44.83 (IQR: 26.98-69.07) and the median IS was 3 (IQR: 2-4). Forty-two patients (31.8%) had IR, 75 (56.8%) had NAFLD, 75 (56.8%) had MetS and 36 (27.3%) had a IS =4. Patients with IS =4 showed higher levels of FLI (60.6 vs. 36.84; p< 0.05) and HOMA-index (2:41 vs. 1:56; p<0.05) than patients with IS<4. The logarithmic regression showed that for every increase of FLI was observed an increase of the IS 0.44% (p<0.01). No relationship was found, however, between Homa-index and IS. The multivariate logistic regression analysis, showed that the presence of NAFLD is an independent risk factor for IS =4 (OR: 2.84; p< 0.05). CONCLUSIONS We have demonstrated that the FLI, expression of NAFLD, is associated with a more severe inflammatory infiltrate prostate. In particular, for each increase of FLI it was observed an increase of 0.44 % of the severity of the inflammation. Finally, the presence of NAFLD increases the risk of having a severe inflammatory infiltrate (SI =4). These results may be useful in order to assess in detail the possible interaction between fatty liver and intra prostatic inflammation. The presence of IR was not found to play a key role for prostate inflammation. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e602 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Giorgio Ivan Russo More articles by this author Sebastiano Cimino More articles by this author Giulio Reale More articles by this author Daniele Urzì More articles by this author Luca Vanella More articles by this author Fabio Motta More articles by this author Rosario Caltabiano More articles by this author Lidia Puzzo More articles by this author Valeria Sorrenti More articles by this author Giuseppe Morgia More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...