MP43-16 CAROTID ATHEROSCLEROSIS EXPRESSED BY INCREASED INTIMA MEDIA THICKNESS IS ASSOCIATED WITH LOW ADHERENCE TO MEDITERRANEAN DIET IN ERECTILE DYSFUNCTION PATIENTS

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research I1 Apr 2014MP43-16 CAROTID ATHEROSCLEROSIS EXPRESSED BY INCREASED INTIMA MEDIA THICKNESS IS ASSOCIATED WITH LOW ADHERENCE TO MEDITERRANEAN DIET IN ERECTILE DYSFUNCTION PATIENTS A. Rempelakos, Ch Vlachopoulos, K. Makarounis, N. Ioakimidis, A. Katevatis, A. Aggelis, D. Karagiannis, and Ch Fasoulakis A. RempelakosA. Rempelakos More articles by this author , Ch VlachopoulosCh Vlachopoulos More articles by this author , K. MakarounisK. Makarounis More articles by this author , N. IoakimidisN. Ioakimidis More articles by this author , A. KatevatisA. Katevatis More articles by this author , A. AggelisA. Aggelis More articles by this author , D. KaragiannisD. Karagiannis More articles by this author , and Ch FasoulakisCh Fasoulakis More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1173AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail Introduction and Objectives The Mediterranean type of diet, rich in fruits, legumes, vegetables and nuts, is a healthy dietary pattern, gaining widely recognition as a non-pharmaceutical mean for cardiovascular disease prevention due to its antioxidant components and anti-inflammatory properties. Endothelial dysfunction and subclinical inflammation are important pathophysiologic mechanisms underlying both vasculogenic erectile dysfunction (ED) and atherosclerosis in other vascular beds. Increased carotid IMT (>0,9mm) relates to traditional risk factors and associates with an unfavorable cardiovascular outcome. Purpose of our study is to investigate the association of Mediterranean type of diet with structural changes in large arteries in ED patients, a relation which has not been defined yet. Methods Forty-five ED patients (aged 56±11 years) underwent carotid ultrasound for evaluation of intima medial thickness (IMT) in the common carotid artery. Overall assessment of dietary habits was evaluated through a special diet score (the Med-DietScore, theoretical range 0–55), which assesses adherence to the Mediterranean dietary pattern. Higher values on the score indicate greater adherence to this pattern and, consequently, healthier dietary habits. Results Med-diet score was significantly associated with age (r=-0.215, P<0.05) systolic and pulse pressure (r=-0.198 and r=-0.277, respectively, all P<0.05). In univariate analysis Med-DietScorewas inversely associated with carotid IMT (r=-0.43, P<0.001, figure). In order to further evaluate the impact of Mediterranean diet on carotid wall thickness, multiple linear regression analysis was applied, which revealed that MedDiet Score was inversely associated with IMT after adjustment for history and treatment of hypertension, hypercholesterolemia, diabetes mellitus, as well as use of statinsand smoking (b = -0.305, p<0.01). Patients with a mean IMT >0.9 mmhad significantly lower Med-Diet Score as compared to subjects with lower IMT values (27±4 vs 33±5, P<0.05). Conclusions The inverse association between Med-Diet Score and carotid IMT indicates an unhealthy dietary life style in ED patients that contributes to an adverse cardiovascular profile and may help in preventing further vascular damage by adapting healthier dietary habits. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e484 Advertisement Copyright & Permissions© 2014MetricsAuthor Information A. Rempelakos More articles by this author Ch Vlachopoulos More articles by this author K. Makarounis More articles by this author N. Ioakimidis More articles by this author A. Katevatis More articles by this author A. Aggelis More articles by this author D. Karagiannis More articles by this author Ch Fasoulakis More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...