MP43-10 HIGH-PRECISION EVALUATION OF SYSTEMIC ENDOTHELIAL FUNCTION IN THE COMPLEX DIAGNOSIS OF ERECTILE DISORDERS.

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation I1 Apr 2015MP43-10 HIGH-PRECISION EVALUATION OF SYSTEMIC ENDOTHELIAL FUNCTION IN THE COMPLEX DIAGNOSIS OF ERECTILE DISORDERS. Oleg Apolikhin, Evgeny Efremov, Yaroslav Melnik, and Stepan Krasnyak Oleg ApolikhinOleg Apolikhin More articles by this author , Evgeny EfremovEvgeny Efremov More articles by this author , Yaroslav MelnikYaroslav Melnik More articles by this author , and Stepan KrasnyakStepan Krasnyak More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1617AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES It has been found that the leading pathophysiological mechanism of arteriogenic erectile dysfunction (ED) is a violation of the endothelial function of cavernous arteries. The increased interest in the issue due to the fact that endothelial dysfunction is functionally reversible. Given the central role of endothelial function in arteriogenic ED and often subjective indicators of endothelial function caused by, resulting from the postcompressive ultrasonic measurement technique requires a more precise and perfect. The evaluation of postcompressive reactive hyperemia index (RHI) is a modern diagnostic tool, which has a high precision determination of the state of endothelial function. METHODS We conducted an assessment of endothelial function in 126 men complaining of erectile dysfunction (42,6 ± 6,8 years). All patients filled the International Index of Erectile Function questionnaire (IIEF). Waist circumference, blood pressure, blood chemistry and penile duplex Doppler ultrasound were also assessed. RESULTS The regression analysis and determination of the Spearman rank correlation coefficient (p <0.05) was performed. The analysis shown a high degree of correlation of endothelial dysfunction with increased blood glucose more than 6.0 mmol/l (r = 0,75), moderate with a waist circumference greater than 94 cm (r = 0,65), age (r = 0,63), increased triglycerides (r = 0,6), decreased high density cholesterol levels (r = 0,5), increased low density cholesterol (r = 0,48), reduced number of points by IIEF (r = 0,45), the lowest degree of association with the identified reduced peak systolic velocity (r = 0,3), low Index of resistance (r = 0,28), end diastolic velocity (r = 0,2), elevated blood pressure> 130 mm Hg (r = 0,2), retention time of blood flow in deep dorsal vein > 15 minutes (r = 0,1). CONCLUSIONS The evaluation of postcompressive reactive hyperemia index is a highly accurate method of assessing systemic endothelial function in the complex diagnosis of ED. Polyethiologic nature of ED requires a systematic approach to the problem and the evaluation of endothelial function in all patients. ED is a predictor of cardiovascular dysfunction, and it is necessary to examine not only the the local penile blood flow, but also to assess systemic endothelial function. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e521 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Oleg Apolikhin More articles by this author Evgeny Efremov More articles by this author Yaroslav Melnik More articles by this author Stepan Krasnyak More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...