MP43-07 PROTECTIVE EFFECT OF TADALAFIL IN A NOVEL RAT MODEL OF CHRONIC PENILE ISCHEMIA

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research I1 Apr 2014MP43-07 PROTECTIVE EFFECT OF TADALAFIL IN A NOVEL RAT MODEL OF CHRONIC PENILE ISCHEMIA Norifumi Sawada, Masanori Nomiya, Mona Zarifpour, Masayuki Takeda, and Karl-Erik Andersson Norifumi SawadaNorifumi Sawada More articles by this author , Masanori NomiyaMasanori Nomiya More articles by this author , Mona ZarifpourMona Zarifpour More articles by this author , Masayuki TakedaMasayuki Takeda More articles by this author , and Karl-Erik AnderssonKarl-Erik Andersson More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1164AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail Introduction and Objectives Oxidative stress induced by atherosclerosis accelerates ischemia and structural damage of penile corporal tissue and may produce erectile dysfunction. We tested the protective effects of tadalafil in a novel rat model of chronic penile ischemia. Methods Adult male Sprague-Dawley rats were divided into three groups (control, arterial injury: AI; AI with tadalafil treatment: AI-tada). The AI and AI-tada groups underwent endothelial bilateral injury of the iliac arteries and received a 2% cholesterol diet. Tadalafil (2 mg/kg/day) was administered for 8 weeks. The control group received a regular diet. After 8 weeks, apomorphine test was performed in each group. Corporal tissues were then processed for histological, pharmacological, and immunohistochemical studies. Results The iliac arteries from the AI showed neo-intimal proliferation and vascular occlusion. This was not prevented by tadalafil treatment. Erectile responses in AI group were significantly reduced, but were normalized in the in AI-tadalafil group (Figure 1AB). The percentage of collagen was significantly increased in AI the group but was almost normalized in the AI-tada group. (Figure 2AB) Electrical field stimulation-induced relaxation was decreased in AI group, but improved significantly in the AI-tada group (P < 0.05). (Figure 3) Conclusions Arterial occlusive disease caused chronic penile ischemia and resulted in reduced erectile function and structural changes in corporal tissue. These changes could be prevented by tadalafil treatment. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e479 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Norifumi Sawada More articles by this author Masanori Nomiya More articles by this author Mona Zarifpour More articles by this author Masayuki Takeda More articles by this author Karl-Erik Andersson More articles by this author Expand All Advertisement Advertisement PDF DownloadLoading ...