MP43-05 EFFECT OF BUPROPION AND TADALAFIL COMBINATION THERAPY IN FEMALE RAT HYPOACTIVE SEXUAL DESIRE DISORDER MODEL

Abstract

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research I1 Apr 2014MP43-05 EFFECT OF BUPROPION AND TADALAFIL COMBINATION THERAPY IN FEMALE RAT HYPOACTIVE SEXUAL DESIRE DISORDER MODEL Hana Yoon, Hyun-suk Yoon, Bong-suk Shim, Young-yo Park, Woo-sik Chung, Dong-hyun Lee, and Kwang-hyun Kim Hana YoonHana Yoon More articles by this author , Hyun-suk YoonHyun-suk Yoon More articles by this author , Bong-suk ShimBong-suk Shim More articles by this author , Young-yo ParkYoung-yo Park More articles by this author , Woo-sik ChungWoo-sik Chung More articles by this author , Dong-hyun LeeDong-hyun Lee More articles by this author , and Kwang-hyun KimKwang-hyun Kim More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1162AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail Introduction and Objectives Hypoactive sexual desire disorder (HSDD) in female sexual dysfunction takes significant portion of female sexual dysfunction, but its treatment modalities are few. Bupropion is known to have increase sexual desire in serotonin reuptake inhibitor(SSRI) induced HSDD and tadalafil is well known PDE5 inhibitor. In this study, we aimed to investigate the efficacy and safety of combination treatment of bupropion and tadalafil in female rat HSDD model. Methods Bilateral oophorectomized female Sprague-Dawley rats were used as sub-primed HSDD model. In this model, after 2 weeks of oophorectomy, estradiol(2ug) was injected subcutaneously (SQ) before every sexual mating. Experimental groups are VH (Vehicle, injection of sesame oil), B (Bupropion 20mg/Kg, daily, SQ), P (tadalafil 2mg/kg, daily, PO), PB (Bupropion 20mg/Kg SQ with tadalafil 2mg/kg PO, daily) . At baseline, 7th day, and 14th day of drug administration, sexual behaviors were observed in specially designed mating cage. Sexual behaviors were analyzed as proceptive behavior(darts and hops), receptive behavior(lordosis), paced mating behavior(mean time of exit (sec/min). Results Drug administered group(B,P, and PB) were all significantly improved sexual behavior analysis compared with VH group. At 14th day of drug administration, combination treatment group(PB) showed more significant improvement in proceptive, receptive behaviors and less avoidance time than other three(VH, B, and P) groups(p<0.01 by ANOVA). There were no drug related death or adverse reactions. Conclusions In female rat HSDD model, combination treatment of bupropion and tadalafil showed significant improvement of sexual behavior than single drug treatment with time-correlation. This supports that combination of bupropion and tadalafil may have beneficial effect on human HSDD. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e478 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Hana Yoon More articles by this author Hyun-suk Yoon More articles by this author Bong-suk Shim More articles by this author Young-yo Park More articles by this author Woo-sik Chung More articles by this author Dong-hyun Lee More articles by this author Kwang-hyun Kim More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...