MP43-04 EFFECTS OF AGE ON TESTICULAR FUNCTION AND THE SPERM RETRIEVAL RATE IN MEN WITH NONOBSTRUCTIVE AZOOSPERMIA

Abstract

You have accessJournal of UrologyCME1 Apr 2023MP43-04 EFFECTS OF AGE ON TESTICULAR FUNCTION AND THE SPERM RETRIEVAL RATE IN MEN WITH NONOBSTRUCTIVE AZOOSPERMIA Shoichiro Iwatsuki, Yukihiro Umemoto, Takumi Kito, Tomoki Takeda, Satoshi Nozaki, and Takahiro Yasui Shoichiro IwatsukiShoichiro Iwatsuki More articles by this author , Yukihiro UmemotoYukihiro Umemoto More articles by this author , Takumi KitoTakumi Kito More articles by this author , Tomoki TakedaTomoki Takeda More articles by this author , Satoshi NozakiSatoshi Nozaki More articles by this author , and Takahiro YasuiTakahiro Yasui More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003289.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: We previously reported an increase in the age of men with nonobstructive azoospermia (NOA) (AUA Annual Meeting 2020). It is important to determine age-induced effects on testicular function in men with NOA. We investigated age-induced changes in testicular endocrine function and the sperm retrieval rate (SRR) during microdissection testicular sperm extraction in men with NOA. METHODS: We investigated 323 men with idiopathic NOA. Patients were categorized into the following age-based groups: 20 s (20–30 years, n=64), 30 s (30–40 years, n=201), and >40 s (>40 years, n=58). We retrospectively recorded testicular volume, serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (TT), and anti-Mullerian hormone (AMH) levels, and SRRs. RESULTS: Testicular volumes in groups 20 s, 30 s, and >40 s were 9.5±4.3 vs. 9.1±4.0 vs. 7.9±3.9 mL, p<0.05 (Jonckheere-Terpstra trend test). Although we observed no intergroup differences in serum LH and TT levels, FSH levels significantly increased with age (22.4±13.3 vs. 26.9±13.2 vs. 26.8±15.3 mIU/mL, p<0.05) as did serum AMH levels (4.4±4.3 vs. 7.9±6.3 vs. 9.2±7.0 ng/mL, p<0.01). SRRs in the 20 s, 30 s, and 40 s groups were 12.5 vs. 28.4 vs. 36.2%, p<0.05 (Cochran-Armitage trend test). CONCLUSIONS: We observed age-induced testicular atrophy and increased serum FSH and AMH levels, which highlight age-induced testicular function decline in men with NOA and suggest that NOA may be progressive despite favorable SRRs in older men. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e602 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shoichiro Iwatsuki More articles by this author Yukihiro Umemoto More articles by this author Takumi Kito More articles by this author Tomoki Takeda More articles by this author Satoshi Nozaki More articles by this author Takahiro Yasui More articles by this author Expand All Advertisement PDF downloadLoading ...