MP41-18 RELATIONSHIP BETWEEN DIETARY PROTEIN INTAKE AND URINE OXALATE

Abstract

You have accessJournal of UrologyStone Disease: Medical Therapy1 Apr 2015MP41-18 RELATIONSHIP BETWEEN DIETARY PROTEIN INTAKE AND URINE OXALATE Jonathan Shoag, Yan Song, Natalia Hernandez, Joshua Halpern, Sameer Mittal, and Brian Eisner Jonathan ShoagJonathan Shoag More articles by this author , Yan SongYan Song More articles by this author , Natalia HernandezNatalia Hernandez More articles by this author , Joshua HalpernJoshua Halpern More articles by this author , Sameer MittalSameer Mittal More articles by this author , and Brian EisnerBrian Eisner More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1646AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES A single previous study demonstrated that dietary protein intake may be associated with urine oxalate excretion. We evaluated the relationship between dietary protein intake and urine oxalate excretion in a cohort of stone formers. METHODS A retrospective review was performed of a metabolic stone database at a tertiary care academic hospital. Univariate and multivariate analysis was performed to evaluate the relationship between urine urea nitrogen (a known surrogate for dietary protein intake) and urine oxalate. Multivariate models adjusted for age, gender, body mass index, race, hypertension, diabetes, medications, and urinary constituents (volume, sodium, potassium, phosphorus, creatinine, sulfate, pH). RESULTS Six hundred two (602) patients were evaluated. Mean age was 52.5 (SD 14.3), mean BMI was 28.3 (SD 6.8), gender prevalence was 37% female:63% male, 27% of patients had hypertension and 10% of patients has diabetes mellitus. Mean urine oxalate excretion was 38.5 mg/day (SD 15.3). On univariate linear regression, dietary protein intake (urine urea nitrogen) was significantly associated with urinary oxalate excretion (β = 1.48, 95% CI 1.24 to 1.73, p < 0.001). On multivariate logistic regression controlling for confounders, increasing quintile of dietary protein intake was associated with significant increases in urine oxalate excretion (p = 0.03 for trend). CONCLUSIONS Dietary protein intake appears to be significantly associated with urine oxalate excretion. Prospective metabolic studies would be useful to confirm this finding. These data may be used in the future to help counsel stone formers on appropriate dietary therapies. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e507 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jonathan Shoag More articles by this author Yan Song More articles by this author Natalia Hernandez More articles by this author Joshua Halpern More articles by this author Sameer Mittal More articles by this author Brian Eisner More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...