MP41-09 A PROSPECTIVE RANDOMIZED STUDY TO EVALUATE THE OUTCOME OF ALPHA BLOCKERS AND THE COMBINATION WITH METHYLPREDNISOLONE IN MEDICAL EXPULSIVE THERAPY FOR LOW ER URETERAL STONES

Abstract

You have accessJournal of UrologyStone Disease: Medical Therapy1 Apr 2015MP41-09 A PROSPECTIVE RANDOMIZED STUDY TO EVALUATE THE OUTCOME OF ALPHA BLOCKERS AND THE COMBINATION WITH METHYLPREDNISOLONE IN MEDICAL EXPULSIVE THERAPY FOR LOW ER URETERAL STONES Waleed Shabana, Mohamed Teleb, Tamer Dawod, and Mahmoud Eladl Waleed ShabanaWaleed Shabana More articles by this author , Mohamed TelebMohamed Teleb More articles by this author , Tamer DawodTamer Dawod More articles by this author , and Mahmoud EladlMahmoud Eladl More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.1637AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To compare the safety and efficacy of tamsulosin, alfuzocin and their combinations with methylprednisolone in medical management of lower ureteral stones. METHODS Between September 2012 and June 2014 patients diagnosed with single lower ureteral stone ≤ 10 mm in longest dimension were enrolled in this study. Patients with urinary tract infection, severe hydronephrosis, pregnancy, hypertension, diabetes, ulcer disease, or renal insufficiency were excluded from the study. According to the medication added to the analgesic anti-inflammatory, patients were stratified into 4 groups, 53 patients each. Group I received tamsulosin 0.4 mg daily. In group II methylprednisolone 8 mg daily is added to tamsulosin. Group III received alfuzocin 10 mg once daily. In group IV patients received alfuzocin and methylprednisolone. The treatment was continued until stone expulsion or to a maximum of 2 weeks. Patients' demographics, stone criteria stone free rate were calculated and analyzed. Kaplan Meier analysis of time to achieve stone expulsion was done and analyzed using Log Rank test with P < 0.05 considered significant. RESULTS The mean stone maximal dimension was 7.8 ± 1.5, 8.1 ± 1.3, 7.9 ± 1.6 and 8.0 ± 1.4 in groups I, II, III and IV respectively. Group II and IV had significantly higher stone free rates in comparison to group I and III (p < 0.05), whilst there were no statistically significant differences between group I and III as well as between group II and IV. Kaplan Meier analysis of time to stone expulsion revealed no statistical difference among the 4 groups with p < 0.05. Three (5.7%) patients of group II and two (3.8%) patients of group IV developed transient hyperglycemia which resolved after stoppage of methylprednisolone. CONCLUSIONS The combination of alfuzosin or tamsulosin with methylprednisolone is effective and safe for management of lower ureteral stones less than 1 cm. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e503 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Waleed Shabana More articles by this author Mohamed Teleb More articles by this author Tamer Dawod More articles by this author Mahmoud Eladl More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...