MP41-02 CLINICAL AND PATHOLOGIC CHARACTERIZATION OF ERG EXPRESSION AND TESTOSTERONE IN AFRICAN AMERICANS

Abstract

You have accessJournal of UrologyProstate Cancer: Basic Research III1 Apr 2014MP41-02 CLINICAL AND PATHOLOGIC CHARACTERIZATION OF ERG EXPRESSION AND TESTOSTERONE IN AFRICAN AMERICANS Michael Degon, Denise Young, Yongmei Chen, Gyorgy Petrovics, Jennifer Cullen, Jacob Kagan, Sudhir Srivastava, David McLeod, Albert Dobi, Isabell Sesterhenn, and Shiv Srivastava Michael DegonMichael Degon More articles by this author , Denise YoungDenise Young More articles by this author , Yongmei ChenYongmei Chen More articles by this author , Gyorgy PetrovicsGyorgy Petrovics More articles by this author , Jennifer CullenJennifer Cullen More articles by this author , Jacob KaganJacob Kagan More articles by this author , Sudhir SrivastavaSudhir Srivastava More articles by this author , David McLeodDavid McLeod More articles by this author , Albert DobiAlbert Dobi More articles by this author , Isabell SesterhennIsabell Sesterhenn More articles by this author , and Shiv SrivastavaShiv Srivastava More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1219AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail Introduction and Objectives African-American men are more likely to be diagnosed with prostate cancer and more likely to die from prostate cancer then Caucasian Americans prompting intense research for determining causal molecular alterations. In recent years substantial progress has been made in defining the causal role and prevalence of ERG oncogene in prostate tumorigenesis. However, only limited number of studies has examined the frequencies of ERG in African American prostate cancer cases. The objective of the current study is to determine ERG oncoprotein frequencies and correlation with patient demographics, tumor pathology, cancer progression, and biochemical recurrence in prostatectomy specimens of African-American men. Methods In this study we have included hormone naïve African-American prostate cancer patients presenting for radical prostatectomy at a single institution over an 18 year period with 2 years of follow up. Whole-mounted radical prostatectomy specimens from 306 African-American men were evaluated by immunohistochemistry with the mouse monoclonal anti-ERG antibody, 9FY. These results were then correlated with clinical and pathologic variables. Results Consistent with previous reports from our laboratory and from others, frequencies of ERG oncoprotein were 26% in index tumors and 48% when any tumors were ERG positive in a whole-mounted section. We have found that ERG positive tumors were more likely present in younger African-American men. ERG positive tumors were significantly enriched in lower grade tumors, and ERG positive tumors correlated with higher testosterone levels. Conclusions ERG positivity of index tumors correlates with higher testosterone levels and younger age at radical prostatectomy in African-Americans. Furthermore, higher nuclear grade is more frequent in ERG positive tumors. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e450-e451 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Michael Degon More articles by this author Denise Young More articles by this author Yongmei Chen More articles by this author Gyorgy Petrovics More articles by this author Jennifer Cullen More articles by this author Jacob Kagan More articles by this author Sudhir Srivastava More articles by this author David McLeod More articles by this author Albert Dobi More articles by this author Isabell Sesterhenn More articles by this author Shiv Srivastava More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...