MP40-14 COGNITIVE EFFECTS OF TRANSDERMAL OXYBUTYNIN IN ELDERLY PATIENTS WITH OVERACTIVE BLADDER SYNDROME

Abstract

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Female Incontinence: Therapy I1 Apr 2017MP40-14 COGNITIVE EFFECTS OF TRANSDERMAL OXYBUTYNIN IN ELDERLY PATIENTS WITH OVERACTIVE BLADDER SYNDROME Carlos Muller-Arteaga, Jose Emilio Batista Miranda, Carmen Zubiaur, Ainara Rabade Ferreiro, Rafael El Khoury Moreno, Gonzalo Morales Solchaga, Javier Casas Nebra, Manuel Leva Vallejo, Oscar Gonzalez Garcia, Salvador Arlandis-Guzman, and Carlos Errando-Smet Carlos Muller-ArteagaCarlos Muller-Arteaga More articles by this author , Jose Emilio Batista MirandaJose Emilio Batista Miranda More articles by this author , Carmen ZubiaurCarmen Zubiaur More articles by this author , Ainara Rabade FerreiroAinara Rabade Ferreiro More articles by this author , Rafael El Khoury MorenoRafael El Khoury Moreno More articles by this author , Gonzalo Morales SolchagaGonzalo Morales Solchaga More articles by this author , Javier Casas NebraJavier Casas Nebra More articles by this author , Manuel Leva VallejoManuel Leva Vallejo More articles by this author , Oscar Gonzalez GarciaOscar Gonzalez Garcia More articles by this author , Salvador Arlandis-GuzmanSalvador Arlandis-Guzman More articles by this author , and Carlos Errando-SmetCarlos Errando-Smet More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.1261AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Oxybutynin is a drug that has proven effective in the treatment of overactive bladder. With the oral presentation, a deterioration in cognitive function is described. The transdermal formulation has shown a decrease of the active metabolite of oxybutynin (N-DEO) involved in the onset of side effects. Cognitive impairment of anticholinergic drugs are related to passage through the blood brain barrier and antagonism of M1 receptors in the central nervous system being the elderly population more susceptible.Objective: To determine if there is impairment of cognitive function in elderly patients, between 65 and 80 years of age, treated with transdermal oxybutynin. As secondary objectives assessed the efficacy of the drug and adherence. METHODS Observational, retrospective, multicenter study. Patients diagnosed with overactive bladder who met the criteria for inclusion / exclusion were assessed at office and treatment was indicated with Oxybutynin transdermal according to routine clinical practice and recommendations for use according to data sheet. Specific questionnaires pathology (Bladder Self-Assestment questionnaire (BSAQ), Patient Perception Bladder Control (PPBC)), of Adherence (Morisky-Green Test) and Assessment of Cognitive function (Impaired Memory, Test, Clock Drawing test) at the start and in the follow-up visit at 4 weeks of treatment were administered. Statistical analysis: Results were treated with relative frequency measurement. For continuous variables, central tendency measures were used for comparisons Student t test, Wilcoxon and Chi-square test was used. The level of statistical significance was set at <0.05 RESULTS A total of 70 patients were evaluable with an average age of 71.37 years, 71.4% were women, 51.4% with basic education and 70% come from the urban environment with an average BMI of 28.68. Impaired Memory, Test results before and after treatment showed no significant differences in any of the areas of assessment of cognitive function. Similarly, no differences were observed in the Drawing Clock Test. Regarding adherence to treatment was 84% with improvement in symptoms and the PPBC and BSAQ questionnaires. CONCLUSIONS In our study not impaired cognitive function in elderly patients with overactive bladder syndrome treated with transdermal oxybutynin was observed © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e528 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Carlos Muller-Arteaga More articles by this author Jose Emilio Batista Miranda More articles by this author Carmen Zubiaur More articles by this author Ainara Rabade Ferreiro More articles by this author Rafael El Khoury Moreno More articles by this author Gonzalo Morales Solchaga More articles by this author Javier Casas Nebra More articles by this author Manuel Leva Vallejo More articles by this author Oscar Gonzalez Garcia More articles by this author Salvador Arlandis-Guzman More articles by this author Carlos Errando-Smet More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...