MP4-01 DEVELOPMENT OF INTERMEDIATE AND HIGH-RISK PROSTATE CANCER AFTER TESTICULAR CANCER

Abstract

You have accessJournal of UrologyProstate Cancer: Epidemiology & Natural History I1 Apr 2015MP4-01 DEVELOPMENT OF INTERMEDIATE AND HIGH-RISK PROSTATE CANCER AFTER TESTICULAR CANCER Andrew Riggin and M. Minhaj Siddiqui Andrew RigginAndrew Riggin More articles by this author and M. Minhaj SiddiquiM. Minhaj Siddiqui More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.144AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES A history of testicular cancer has been suggested to have an association with an increased risk of developing prostate cancer (PCa) in epidemiology studies. We hypothesized that there may be an increased risk of developing intermediate to high-risk PCa as well. METHODS This is a retrospective case-control study. The Surveillance, Epidemiology and End Results (SEER) registry was queried to identify men with a history of testicular cancer (case group) and men with a history of melanoma (controls). Melanoma was used as a control group because, to our knowledge, there is no association of melanoma and PCa. Men were excluded if they were not 40 years of age or older to allow for sufficient age for PCa diagnosis. PCa incidence was only counted if it occurred at least 5 years after the diagnosis of their primary cancer to allow for possible temporal effect of the primary malignancy. Incidence of total and intermediate to high-risk PCa(Gleason score ≥ 7) was compared using Kaplan-Meier (KM) curves. Cox proportional hazards models were utilized to assess for associations of PCa (JMP 10, SAS Inc). RESULTS 147,044 men with melanoma and 32,435 men with testicular cancer were identified. PCa was diagnosed in 3,205 men. The cumulative incidence of all PCa by age 80 was 2.8% in the control melanoma cohort and 12.6% in the case cohort of men with history of testicular cancer (p<0.0001 for KM survival curves, Figure 1). For intermediate/high-risk disease, the incidence was 1.1% versus 5.8% for each cohort respectively (p<0.0001 for KM survival curves, Figure 2). No association with PCa was seen with non-seminomatous versus seminomatous germ cell tumors. Upon multivariate analysis, testis cancer was associated with an increased risk of all PCa (HR 4.7, p<0.0001) and intermediate/high-risk PCa (HR 5.2, p<0.0001) when controlling for race and radiation history. CONCLUSIONS A history of testicular cancer is associated with an increased risk of intermediate/high risk PCa. Future studies may be warranted to determine if men with a history of testicular cancer should have closer screening for PCa. © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 4SApril 2015Page: e26-e27 Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Andrew Riggin More articles by this author M. Minhaj Siddiqui More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...