MP39-08 PAINFUL URGENCY AND/OR PAINFUL FILLING PREDICTIVE OF SOMATIC SYMPTOMS AND CHRONIC PAIN IN WOMEN WITH OVERACTIVE BLADDER

Abstract

You have accessJournal of UrologyInfections/Inflammation/Cystic Disease of the Genitourinary Tract: Interstitial Cystitis1 Apr 2018MP39-08 PAINFUL URGENCY AND/OR PAINFUL FILLING PREDICTIVE OF SOMATIC SYMPTOMS AND CHRONIC PAIN IN WOMEN WITH OVERACTIVE BLADDER Casey G Kowalik, Sophia Delpe, Melissa R. Kaufman, Roger R. Dmochowski, and W. Stuart Reynolds Casey G KowalikCasey G Kowalik More articles by this author , Sophia DelpeSophia Delpe More articles by this author , Melissa R. KaufmanMelissa R. Kaufman More articles by this author , Roger R. DmochowskiRoger R. Dmochowski More articles by this author , and W. Stuart ReynoldsW. Stuart Reynolds More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1255AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Current theories hypothesize that overactive bladder (OAB) and Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) comprise a spectrum of bladder hypersensitivity with overlapping symptoms. Symptoms of painful urgency and filling are common in women with OAB and may be correlated with more severe urologic symptoms and decreased quality of life. This analysis investigated the relationships of painful urgency and filling with somatic symptoms and chronic pain conditions in women with OAB without an IC/BPS diagnosis. METHODS Women with OAB symptoms and without IC/BPS diagnosis were recruited to complete validated questionnaires assessing urinary symptoms (OAB symptom scale [OAB-ss] and Health Related Quality of Life [OABq-HRQL]), somatic symptoms, and pain syndromes. Participants were categorized into 3 groups, (1) Neither (2) Either or (3) Both, based on their report of painful urgency and/or painful filling. Multivariable regression analyses were performed to determine factors predictive of have either or both painful urgency and/or painful filling. RESULTS Of 218 women with OAB symptoms, 46% (n=101) had neither painful urgency nor painful filling, 43% (n=94) had either, and 11% (n=23) had both. There was an increase in average OAB-SS, pain intensity, and somatic symptom score, and a decrease in OAB-HRQL from neither > either > both. Controlling for age, women with either or both urologic pain symptoms had an increase in somatic symptom score by 1.5 and 3 points and an increase in pain intensity by 3 and 6.5 points, respectively, compared to women in the neither group. Additionally, women with either or both symptoms were 2.9 and 3.5 times more likely to have irritable bowel syndrome and 3.3 and 4.5 times, respectively, more likely to have chronic pelvic pain. CONCLUSIONS In this group of women with OAB, without IC/BPS, the majority reported either painful urgency, painful filling, or both. Experiencing painful urgency and/or filling was associated with increased somatic symptom burden and pain intensity. Additionally, women with either or both symptoms were more likely to have chronic pain conditions, hypothesized to have a common central pathophysiology. These findings support the hypothesis that OAB and IC/BPS diagnoses may represent a continuum of bladder hypersensitivity with women experiencing pain being more likely to also have underlying central sensitization mechanisms. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e512-e513 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Casey G Kowalik More articles by this author Sophia Delpe More articles by this author Melissa R. Kaufman More articles by this author Roger R. Dmochowski More articles by this author W. Stuart Reynolds More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...