MP38-18 METABOLOMICS APPROACH FOR ASSOCIATION WITH OVERACTIVE BLADDER IN MALES: AN IDENTIFICATION OF POTENTIAL TARGETS FOR NEW TREATMENTS

Abstract

You have accessJournal of UrologyUrodynamics/Lower Urinary Tract Dysfunction/Female Pelvic Medicine: Basic Research & Pathophysiology II1 Apr 2018MP38-18 METABOLOMICS APPROACH FOR ASSOCIATION WITH OVERACTIVE BLADDER IN MALES: AN IDENTIFICATION OF POTENTIAL TARGETS FOR NEW TREATMENTS Hiroshi Shimura, Takahiko Mitsui, Satoru Kira, Tatsuya Ihara, Hiroshi Nakagomi, Norifumi Sawada, and Masayuki Takeda Hiroshi ShimuraHiroshi Shimura More articles by this author , Takahiko MitsuiTakahiko Mitsui More articles by this author , Satoru KiraSatoru Kira More articles by this author , Tatsuya IharaTatsuya Ihara More articles by this author , Hiroshi NakagomiHiroshi Nakagomi More articles by this author , Norifumi SawadaNorifumi Sawada More articles by this author , and Masayuki TakedaMasayuki Takeda More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.02.1245AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Lower urinary tract symptoms (LUTS) are a common complaint in aged males and usually have a major impact on their quality of life (QoL). overactive bladder (OAB) is one of the most bothering diseases in LUTS, and sometimes persists even after ordinary therapy, because of the unclear mechanism. On the other hand, metabolomics analysis enables the detection and semi-quantitative measurement of hundreds of unique metabolites from broad range of metabolic pathways, and these approaches can detect metabolites associated with pathophysiological states. In the present study, we identified metabolites from metabolomics approach and investigated association between these metabolites and urgency as a major complaint of OAB. METHODS A total of 58 male participants without apparent neurological diseases at our outpatient clinic were enrolled in the present study. We checked the International Prostate Symptom Score (IPSS) and QOL score from them and divided the patients into two groups; Urgency-group (2 and more: n=32), and Control-group (0 or 1: n=26) in an urgency score of IPSS. Then, we conducted a comprehensive study of plasma metabolites using capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS). Metabolites were compared between Urgency- and Control-groups using Mann-Whitney U test, and biomarkers of OAB in males from metabolites in CE-TOFMS were analyzed using a multivariable logistic regression analysis. RESULTS The mean age was 71.5+/-4.3 years old, and the mean body mass index (BMI) was 23.0+/-2.7. Metabolomics analysis with CE-TOFMS identified 110 metabolites from plasma of participants. In a total of 11 metabolites, there was significant difference or a trend of difference between Urgency- and Control-groups. Regarding these 11 metabolites, a multivariate analysis showed that an increase of Glu and a decrease of Gln, Arg and IMP were associated with urgency in males. CONCLUSIONS From the present study, some metabolic pathways could be involved in incidence of OAB. Particularly, Glu, Gln and Arg are in the same metabolic pathway, and the pathway was associated with metabolic syndrome in the previous study. These metabolic changes may induce OAB, involving metabolic syndrome. Further studies using metabolomics analysis have a potential to detect new biomarkers and develop potential targets for new treatments. © 2018FiguresReferencesRelatedDetails Volume 199Issue 4SApril 2018Page: e508 Advertisement Copyright & Permissions© 2018MetricsAuthor Information Hiroshi Shimura More articles by this author Takahiko Mitsui More articles by this author Satoru Kira More articles by this author Tatsuya Ihara More articles by this author Hiroshi Nakagomi More articles by this author Norifumi Sawada More articles by this author Masayuki Takeda More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...