MP38-20 SEXUAL DYSFUNCTION ISSUES AMONG MEN WITH PSYCHIATRIC COMORBIDITIES: A MANAGEMENT CHALLENGE?

Abstract

You have accessJournal of UrologyCME1 May 2022MP38-20 SEXUAL DYSFUNCTION ISSUES AMONG MEN WITH PSYCHIATRIC COMORBIDITIES: A MANAGEMENT CHALLENGE? Nicolò Schifano, Paolo Capogrosso, Giuseppe Fallara, Edoardo Pozzi, Federico Belladelli, Luigi Candela, Christian Corsini, Massimiliano Raffo, Antonio Costa, Daniele Cignoli, Alessia d'Arma, Luca Boeri, Eugenio Ventimiglia, Rayan Matloob, Vincenzo Mirone, Federico Dehò, Francesco Montorsi, and Andrea Salonia Nicolò SchifanoNicolò Schifano More articles by this author , Paolo CapogrossoPaolo Capogrosso More articles by this author , Giuseppe FallaraGiuseppe Fallara More articles by this author , Edoardo PozziEdoardo Pozzi More articles by this author , Federico BelladelliFederico Belladelli More articles by this author , Luigi CandelaLuigi Candela More articles by this author , Christian CorsiniChristian Corsini More articles by this author , Massimiliano RaffoMassimiliano Raffo More articles by this author , Antonio CostaAntonio Costa More articles by this author , Daniele CignoliDaniele Cignoli More articles by this author , Alessia d'ArmaAlessia d'Arma More articles by this author , Luca BoeriLuca Boeri More articles by this author , Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Rayan MatloobRayan Matloob More articles by this author , Vincenzo MironeVincenzo Mirone More articles by this author , Federico DehòFederico Dehò More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea SaloniaAndrea Salonia More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002592.20AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Sexual dysfunction (SD), including erectile dysfunction (ED), low sexual desire (LSD), orgasmic and ejaculatory dysfunction are frequent complaints among patients with affective disorders and other psychiatric comorbidities. These SD-complaints may commonly arise or worsen with the intake of psychotropic medications. The evidence available regarding these issues management in the real-life practice is currently rather limited. We aimed to describe the clinical features of these patients and their clinical response to PDE5 inhibitors (PDE5Is). METHODS: Socio-demographic and clinical data from 3152 consecutive patients presenting with a primary complaint of ED with or without concomitant SD were retrospectively analysed. Patients with an active diagnosis of affective disorder and taking on a regular basis a psychotropic medication (e.g., antidepressants, mood-stabilizers, antipsychotics and anti-anxiety medications) and those with a Beck’s Depression Index (BDI) >10 were considered having a psychiatric comorbidity. Descriptive statistics tested clinical differences between patients with and without a psychiatric comorbidity. Linear multivariate analysis investigated the association between the clinical features and the post-PDE5I IIEF-EF. RESULTS: Overall, 14.5% of the patients had a psychiatric comorbidity. Among the baseline-clinical-features, age, concurrent sexual complaints other-than-ED, PDE5I-naïve status at first clinical evaluation, BDI, baseline and post-PDE5I IIEF-EF were significantly different among the patients with a psychiatric comorbidity vs. the remaining (all p <0.05) (Table 1). At multivariate analysis, the existence of a psychiatric comorbidity (B=-3.0,p=0.04) and a Charlson Comorbidity Index (CCI) >0 (B=-2.5,p=0.02) predicted lower post-PDE5I IIEF-EF; whilst age was non-significantly associated. CONCLUSIONS: Patients with a psychiatric comorbidity and complaining of SD are frequently encountered in the everyday clinical practice. PDE5Is may be an effective strategy to deal even with these patients, although the efficacy of this strategy may be sub-optimal for some patients, thus outlining the importance of a personalized therapeutic work-up. Source of Funding: No source of funding to be disclosed © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e626 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Nicolò Schifano More articles by this author Paolo Capogrosso More articles by this author Giuseppe Fallara More articles by this author Edoardo Pozzi More articles by this author Federico Belladelli More articles by this author Luigi Candela More articles by this author Christian Corsini More articles by this author Massimiliano Raffo More articles by this author Antonio Costa More articles by this author Daniele Cignoli More articles by this author Alessia d'Arma More articles by this author Luca Boeri More articles by this author Eugenio Ventimiglia More articles by this author Rayan Matloob More articles by this author Vincenzo Mirone More articles by this author Federico Dehò More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement PDF DownloadLoading ...