MP38-14 GUT MICROBIOME ASSOCIATED WITH BLOOD TESTOSTERONE LEVELS IN ELDERLY MEN

Abstract

You have accessJournal of UrologyCME1 May 2022MP38-14 GUT MICROBIOME ASSOCIATED WITH BLOOD TESTOSTERONE LEVELS IN ELDERLY MEN Kazutoshi Fujita, Makoto Matsushita, Koji Hatano, Mitsuhisa Nishimoto, Daisuke Motooka, Eri Banno, Junya Hata, Takafumi Minami, Masahiro Nozawa, Shota Nakamura, Akira Tsujimura, Wataru Obara, Kazuhiro Yoshimura, Hirotsugu Uemura, and Norio Nonomura Kazutoshi FujitaKazutoshi Fujita More articles by this author , Makoto MatsushitaMakoto Matsushita More articles by this author , Koji HatanoKoji Hatano More articles by this author , Mitsuhisa NishimotoMitsuhisa Nishimoto More articles by this author , Daisuke MotookaDaisuke Motooka More articles by this author , Eri BannoEri Banno More articles by this author , Junya HataJunya Hata More articles by this author , Takafumi MinamiTakafumi Minami More articles by this author , Masahiro NozawaMasahiro Nozawa More articles by this author , Shota NakamuraShota Nakamura More articles by this author , Akira TsujimuraAkira Tsujimura More articles by this author , Wataru ObaraWataru Obara More articles by this author , Kazuhiro YoshimuraKazuhiro Yoshimura More articles by this author , Hirotsugu UemuraHirotsugu Uemura More articles by this author , and Norio NonomuraNorio Nonomura More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002592.14AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Testosterone levels have been implicated in a variety of male diseases, such as hypogonadism and sexual funciton. Patients with high-grade prostate cancer had a unique microbiota composition, suggesting that intestinal bacteria could influence the prostate cancer progression via testosterone metabolism. In this study, we determined the relationship between testosterone levels and gut microbiota. METHODS: Fifty-four Japanese men who had negative prostate biopsies were included in the study. The gut microbiota was analyzed by 16S rRNA gene sequencing of bacterial DNA extracted from rectal swabs. The gut microbiota compositions were compared in two groups according to serum testosterone levels above or below 3.5 ng /ml. RESULTS: No significant difference in alpha or beta diversity was observed, but some bacteria belonging to the phylum Firmicutes (Clostridiales, Turicibacter, and Gemella) were increased in the high testosterone group. Serum testosterone level were positively correlated with the relative amount of Firmicutes (rS=0.33, P=0.01), and Firmicutes amount affected serum testosterone levels independent of host factors (Age, BMI, triglyceride, and total cholesterol (β=0.770, P=0.040)). CONCLUSIONS: These results suggest that some intestinal bacteria belonging to phylum Firmicutes influence the testosterone metabolism of elderly men and may affect the pathology of various testosterone-induced diseases, especially male hypogonadism. Source of Funding: Kaken, Yakulto-Bioscience, Japanese Urological Association © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e623 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Kazutoshi Fujita More articles by this author Makoto Matsushita More articles by this author Koji Hatano More articles by this author Mitsuhisa Nishimoto More articles by this author Daisuke Motooka More articles by this author Eri Banno More articles by this author Junya Hata More articles by this author Takafumi Minami More articles by this author Masahiro Nozawa More articles by this author Shota Nakamura More articles by this author Akira Tsujimura More articles by this author Wataru Obara More articles by this author Kazuhiro Yoshimura More articles by this author Hirotsugu Uemura More articles by this author Norio Nonomura More articles by this author Expand All Advertisement PDF DownloadLoading ...