MP38-13 PATHOLOGICAL SIGNIFICANCE OF PERIODONTAL DISEASE IN PATIENTS WITH UROTHELIAL CANCERS: CORRELATION WITH URINARY TRACT RECURRENCE AND OXIDATIVE STRESS

Abstract

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation I (MP38)1 Sep 2021MP38-13 PATHOLOGICAL SIGNIFICANCE OF PERIODONTAL DISEASE IN PATIENTS WITH UROTHELIAL CANCERS: CORRELATION WITH URINARY TRACT RECURRENCE AND OXIDATIVE STRESS Yasuyoshi Miyata, Tomohiro Matsuo, Tsuyoshi Matsuda, Junki Harada, Yuta Mukae, Asato Otsubo, Tsubasa Kondo, Kensuke Mitsunari, Kojiro Ohba, and Hideki Sakai Yasuyoshi MiyataYasuyoshi Miyata More articles by this author , Tomohiro MatsuoTomohiro Matsuo More articles by this author , Tsuyoshi MatsudaTsuyoshi Matsuda More articles by this author , Junki HaradaJunki Harada More articles by this author , Yuta MukaeYuta Mukae More articles by this author , Asato OtsuboAsato Otsubo More articles by this author , Tsubasa KondoTsubasa Kondo More articles by this author , Kensuke MitsunariKensuke Mitsunari More articles by this author , Kojiro OhbaKojiro Ohba More articles by this author , and Hideki SakaiHideki Sakai More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002053.13AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Periodontal disease (PD) involves chronic oral infection and inflammation. In recent years, there is general agreement that PD can affect the pathogenesis and progression of various systemic diseases including malignancies. Moreover, PD leads to the stimulation of oxidative stress in distant organs. The aim of this study was to clarify the pathological roles of PD in patients with urothelial cancer (UC). METHODS: We investigated the relationship between PD and clinicopathological features, outcomes, and oxidative stress in 311 patients with UC (bladder=257, upper urinary tract=54). Patients were divided into the following 3 groups based on the severity of PD: none (n=102), mild (without tooth loss, n=93), and severe (with tooth loss due to PD, n=116). The oxidative stress markers, 8-hydroxy-2-deoxyguanosine (8-OHdG) and malondialdehyde (MDA), were analyzed by immunohistochemistry in UC tissues. RESULTS: In the entire cohort, the severity of PD was positively associated with tumor grade (p=0.039), but not with pT stage or metastasis. Kaplan-Meier survival curves showed that patients with severe PD had a significantly higher incidence of urinary tract recurrence (p<0.001), but not of subsequent metastasis or survival. Furthermore, such a significant relationship between PD and urinary tract recurrence was detected in bladder cancer (p<0.001), but not in upper urinary tract cancer (p=0.570). Therefore, when further analyses were performed in non-muscle invasive bladder cancer (NMIBC, n=190), PD was significantly associated with grade, pT stage, and concomitant carcinoma in situ (p=0.473, 0.002, and <0.001, respectively). Univariate analysis showed that severe PD was a significant predictor of urinary tract recurrence and a multivariate analysis model that included all clinicopathological features, supported these findings (hazard ratio=1.55, 95% confidential interval=1.85–5.60, p<0.001). Moreover, the percentage of cells positive for 8-OHdG and MDA expression in NMIBC tissues with severe PD was significantly higher (p<0.001) compared to those with no or mild PD. CONCLUSIONS: Our results showed that severe PD was associated with the malignant potential of bladder cancer. In particular, PD played important roles in malignant aggressiveness, including urinary tract recurrence in NMIBC. In addition, we propose that the increase in oxidative stress in bladder cancer tissues caused by PD is associated with such pathological mechanisms. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e699-e699 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Yasuyoshi Miyata More articles by this author Tomohiro Matsuo More articles by this author Tsuyoshi Matsuda More articles by this author Junki Harada More articles by this author Yuta Mukae More articles by this author Asato Otsubo More articles by this author Tsubasa Kondo More articles by this author Kensuke Mitsunari More articles by this author Kojiro Ohba More articles by this author Hideki Sakai More articles by this author Expand All Advertisement Loading ...