MP38-06 PREDICTIVE ROLE OF SERUM INFLAMMATORY CYTOKINES IN DETECTION OF BLADDER CANCER

Abstract

You have accessJournal of UrologyBladder Cancer: Epidemiology & Evaluation I (MP38)1 Sep 2021MP38-06 PREDICTIVE ROLE OF SERUM INFLAMMATORY CYTOKINES IN DETECTION OF BLADDER CANCER Mervat Soliman, Ahmed Elkashef, Marwan Anas, Mona El Wassefy, Youssef Mohamed Mosaad, Shereen Salah Metwally, and Yasser Osman Mervat SolimanMervat Soliman More articles by this author , Ahmed ElkashefAhmed Elkashef More articles by this author , Marwan AnasMarwan Anas More articles by this author , Mona El WassefyMona El Wassefy More articles by this author , Youssef Mohamed MosaadYoussef Mohamed Mosaad More articles by this author , Shereen Salah MetwallyShereen Salah Metwally More articles by this author , and Yasser OsmanYasser Osman More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002053.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Inflammation plays a critical role in cellular damage causing various diseases, including cancers. Bladder cancer (BC) is the one of most common cancers worldwide that represents a major cause of morbidity and mortality. However, early diagnosis of BC may improve the natural history of the disease. Therefore, we assessed the role of serum inflammatory cytokine levels in detection of BC. METHODS: 120 individuals (60 BC patients and 60 healthy controls) were included in the study. Blood samples were collected, so total RNA extract was isolated and analyzed by a reverse transcriptase-polymerase chain reaction assay for detection of interleukin (IL)-6, IL-12, IL-27 and tumor necrosis factor (TNF)-α levels. Tissue samples were also collected by transurethral resection (TUR) for routine histopathological examination. RESULTS: The study included 104 males (86.6%) and 16 females (13.4%). Mean ages were 66.4±8.8 years old. BC patients significantly showed higher levels of IL-6 and TNF-α expression and lower expression levels of IL-27 relative to the healthy controls (p ˂0.001). Multivariate logistic regression identified IL-6, IL-27 and TNF-α as independent predictors for BC (table 1). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and overall accuracy of IL-6, IL-12, IL-27 and TNF-α were shown in table 2 and figure 1. CONCLUSIONS: Serum inflammatory cytokines; IL-6, IL-27 and TNF-α might be regarded as promising useful biomarkers to predict BC. Source of Funding: None © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 206Issue Supplement 3September 2021Page: e694-e694 Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mervat Soliman More articles by this author Ahmed Elkashef More articles by this author Marwan Anas More articles by this author Mona El Wassefy More articles by this author Youssef Mohamed Mosaad More articles by this author Shereen Salah Metwally More articles by this author Yasser Osman More articles by this author Expand All Advertisement Loading ...