MP36-19 INVESTIGATING RISK FACTORS OF NEPHROLITHIASIS FROM THE CLINICAL IMAGES TO THE GENETIC BIOINFORMATICS

Abstract

You have accessJournal of UrologyImaging/Radiology: Uroradiology I (MP36)1 Apr 2020MP36-19 INVESTIGATING RISK FACTORS OF NEPHROLITHIASIS FROM THE CLINICAL IMAGES TO THE GENETIC BIOINFORMATICS Zhu Yunpeng* and Zeng Xiaoyong Zhu Yunpeng*Zhu Yunpeng* More articles by this author and Zeng XiaoyongZeng Xiaoyong More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000880.019AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: To investigate the correlation among abdominal aortic calcification, the calcification of renal papillary tips and nephrolithiasis though imaging in CT and bioinformatics methods. METHODS: This retrospective study included 163 kidney stone-formers and 168 age- and sex-matched control participants without urolithiasis and histories of urolithiasis. The clinical data including age, gender and comorbidities were collected. Aortic calcification index (ACI) of aorta abdominalis, bone mineral density (BMD) of the first lumbar vertebra and the attenuation of renal papillary tips were measured in CT. Multivariate logistic regression analysis was performed to the correlation among ACI, the attenuation of renal papillary tips and nephrolithiasis. Additionally, through the GEO database, the gene expression analyses of aortic calcification (GSE100927) and nephrolithiasis (GSE100927) were performed to evaluate the inner connection in the level of genetic expression. RESULTS: These data showed that the stone-formers had the higher attenuation of renal papillary tips. There was no significant difference in the prevalence of abdominal aortic calcification, however, ACI of participants with abdominal aortic calcification was significantly higher in the stone group. Multivariate logistic regression analysis showed that ACI and the attenuation of renal papillary tips were significantly correlated with nephrolithiasis. Through bioinformatics methods, the same Differentially Expressed Genes of 8 upregulated genes and 17 downregulated genes were screened out and we found that some important signaling pathways were activated in both nephrolithiasis and arterial calcificatio. CONCLUSIONS: This study demonstrates that the stone-formers have the higher attenuation of renal papillary tips, which gives us a hint that the higher attenuation of renal papillary tips may predict the occurrence nephrolithiasis and is supposed to be a junction between nephrolithiasis and arterial calcification. A significant correlation between aortic calcification and nephrolithiasis was proved again and some important genes and signaling pathways were considered to be the inner connection between nephrolithiasis and arterial calcification. Source of Funding: National Natural Science Foundation of China, Project (No.81570631 and No.81600544) © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e530-e530 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Zhu Yunpeng* More articles by this author Zeng Xiaoyong More articles by this author Expand All Advertisement PDF downloadLoading ...