Abstract

You have accessJournal of UrologyKidney Cancer: Evalution/Staging III1 Apr 2014MP36-10 PRE-OPERATIVE URINE AQUAPORIN-1 CONCENTRATIONS INCREASE WITH TUMOR SIZE IN PATIENTS WITH RENAL CELL CARCINOMA. Jonathan Mobley, Jeremiah Morrissey, R. Sherburne Figenshau, Sam Bhayani, Joel Vetter, Joseph Song, and Evan Kharasch Jonathan MobleyJonathan Mobley More articles by this author , Jeremiah MorrisseyJeremiah Morrissey More articles by this author , R. Sherburne FigenshauR. Sherburne Figenshau More articles by this author , Sam BhayaniSam Bhayani More articles by this author , Joel VetterJoel Vetter More articles by this author , Joseph SongJoseph Song More articles by this author , and Evan KharaschEvan Kharasch More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.1074AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Aquaporin-1 (AQP1) protein expression has been documented in renal cell carcinoma (RCC). We compare pre-operative urine concentrations of AQP1 in patients with clear cell and papillary RCC with control patients undergoing non-urological surgery. We evaluate the effects of tumor size, stage, and grade on urine AQP1 concentrations. METHODS Pre-operative urine samples were obtained from 61 patients undergoing partial or radical nephrectomy for clear cell or papillary RCC and 43 controls matched by age, sex, smoking history, estimated glomerular filtration rate, and weight. Urine AQP1 concentrations were measured using Western blot procedures normalized to the urine creatinine excretion. Evaluations of urine AQP1 based on tumor size, pathological stage, and nuclear grade was performed. RESULTS The median AQP1 levels for the RCC and control group was 53 and 1.5 relative absorbance units per milligram creatinine (Mann-Whitney U, P<0.001). AQP1 levels were positively correlated with tumor size (Spearman Coefficient 0.78, P<0.001). There was an increase in AQP1 levels between pT1a to pT1b and pT1b to pT2, but not from pT2 to pT3 (Mann-Whitney U, P=0.003, P=0.030, and P=0.127, respectively). There was no significant difference found in AQP1 levels based on grade. CONCLUSIONS Urine AQP1 is elevated in patients with clear cell and papillary RCC when compared to controls. These levels increase with tumor size, but do not reflect tumor grade. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e382 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Jonathan Mobley More articles by this author Jeremiah Morrissey More articles by this author R. Sherburne Figenshau More articles by this author Sam Bhayani More articles by this author Joel Vetter More articles by this author Joseph Song More articles by this author Evan Kharasch More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

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